Carrillo-Esper R, Rivero-Martínez JA, Zepeda-Mendoza AD

Idioma: Español
Referencias bibliográficas: 31
Paginas: 738-744
Archivo PDF: 564.66 Kb.

RESUMEN

El síndrome hemofagocítico es una enfermedad poco frecuente, causada por la disfunción de las células citotóxicas y células natural killer, lo que provoca la liberación aberrante de citocinas y resulta en la proliferación y activación de histiocitos con la subsecuente hemofagocitosis. Se conocen dos formas: la primaria o genética y la secundaria o reactiva. Se manifiesta con fiebre, linfadenopatía, hepatoesplenomegalia, exantema maculopapular, citopenias, hipertrigliceridemia e hiperferritinemia. Se ha relacionado con varios virus, entre los que destacan: el virus de Epstein-Barr, citomegalovirus, herpes 6 y 8, parvovirus B-19 y de la inmunodeficiencia humana y existen pocos reportes relacionados con el virus de la influenza A H1N1. El diagnóstico se realiza mediante los datos clínicos, exámenes de laboratorio, estudio histopatológico y biomarcadores séricos. El tratamiento está encaminado a la corrección de la causa desencadenante, también incluye esteroides e inmunosupresores. El objetivo de este trabajo es comunicar un caso clínico de síndrome hemofagocítico.

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