Castillo CY, Riverón FG

Idioma: Español
Referencias bibliográficas: 30
Paginas: 5-11
Archivo PDF: 308.25 Kb.

RESUMEN

Los organismos a partir de su exposición a la atmósfera rica en oxígeno, desarrollaron sistemas de defensa antioxidantes capaces de contrarrestar la toxicidad que pueden generar las especies reactivas del oxígeno. Los componentes del sistema de defensa antioxidante, son muy diversos, los más estudiados son los llamados antioxidantes primarios, que son los que eliminan o previenen la formación de estas especies reactivas. En este grupo se encuentra la familia de las superóxido dismutasas, las que catalizan con una elevada eficiencia, la reacción de dismutación del anión superóxido, y constituyen las únicas enzimas conocidas que actúan sobre un radical. Dentro de este grupo, la superóxido dismutasa 1 forma parte de la primera línea de defensa antioxidante a nivel citosólico, y tanto el aumento como la disminución de la actividad de esta enzima resultan perjudiciales para el organismo. En esta revisión se ofrece una actualización sobre los estudios realizados en relación con la superóxido dismutasa 1 y su vinculación en la patogénesis de algunas enfermedades genéticas.

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