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2013, Número 2

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Rev Esp Cienc Salud 2013; 16 (2)


Cambios epigenéticos en el DNA Papel en lareconstrucción tisular, sistemanervioso central y cáncer

Valle MA

Idioma: Español
Referencias bibliográficas: 33
Paginas: 49-54
Archivo PDF: 672.30 Kb.


RESUMEN

La epigenética estudia los cambios en el DNA que no alteran su secuencia, pero sí afectan la expresión de los genes. Existen muchos tipos de modificaciones, particularmente en el dominio N-terminal de las histonas que conforman el nucleosoma. Estos cambios tienen repercusiones directas en la expresión o represión de genes, con diferentes consecuencias a nivel celular. Una de estas modificaciones es la incorporación de un grupo acetilo en residuos de lisina (acetilación), la cual se ha involucrado en diversos procesos como la sanación de heridas, en enfermedades del sistema nervioso central y en el cáncer. El desarrollo de fármacos, capaces de controlar los cambios epigenéticos generados en diversas enfermedades, es actualmente un campo amplio de estudio y donde se han encontrado resultados prometedores.


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