2014, Número 4
Defectos óseos en artroplastia de revisión de rodilla tratados con aloinjerto óseo y plasma rico en plaquetas
Macule-Beneyto F, Segur-Vilalta J, Vilchez-Cavazos F, Esteban-Navarro P, Vidal-Sicart S, Acosta-Olivo C
Idioma: Español
Referencias bibliográficas: 42
Paginas: 395-401
Archivo PDF: 369.58 Kb.
RESUMEN
Antecedentes: uno de los aspectos más desafiantes de la artroplastia
de revisión de rodilla es el manejo de la pérdida ósea.
Objetivo: demostrar la capacidad de incrementar la densidad mineral
ósea en áreas con pérdida ósea, mediante el uso de plasma rico en
plaquetas.
Material y métodos: estudio prospectivo, aleatorizado, cegado;
efectuado con pacientes a quienes se realizó artroplastia de revisión de
rodilla con pérdida ósea metafisiaria de tibia. Los pacientes se asignaron
al azar a dos grupos para rellenar los defectos con aloinjerto óseo
liofilizado con plasma rico en plaquetas (grupo experimental, n= 9), y
otro grupo que sólo recibió el injerto óseo liofilizado (grupo control,
n= 7). En ambos grupos la evaluación de la densidad mineral ósea se
hizo con absorciometría de rayos X de energía dual (DXA) antes de la
operación, al mes, seis meses, y un año después de la cirugía.
Resultados: se estudiaron 16 pacientes sin diferencias significativas
entre ambos grupos en la densidad mineral ósea durante el periodo
de seguimiento.
Conclusiones: el plasma rico en plaquetas no demostró incrementar la
densidad mineral ósea en pacientes con defectos óseos por artroplastia
de revisión de rodilla.
REFERENCIAS (EN ESTE ARTÍCULO)
Huff TW, Sculco TP. Management of Bone Loss in Revision Total Knee Arthroplasty. J Arthroplasty 2007;22(7 Suppl):32-36.
Bush JL, Wilson JB, Vail TP. Management of Bone Loss in Revision Total Knee Arthroplasty. Clin Orthop Relat Res 2006:452:186-192.
Backstein D, Safir O, Gross A. Management of Bone Loss: Structural Grafts in Revision Total Knee Arthroplasty. Clin Orthop Relat Res 2006;446:104-112.
Engh GA, Ammeen DJ. Use of Structural Allograft in Revision Total Knee Arthroplasty in Knees with Severe Tibial Bone Loss. J Bone Joint Surg Am 2007;89(12):2640-2647.
Cuckler JM. Bone loss in Total Knee Arthroplasty: Graft augment and options. J Arthroplasty 2004;19(4 Suppl 1):56-58.
Mabry TM, Hanssen AD. The Role of Stem and Augments for Bone Loss in Revision Knee Arthroplasty. J Arthroplasty 2007;22(4 suppl 1):56-60.
Radnay CS, Scuderi GR. Management of Bone Loss: Augments, Cones, Offset Stems. Clin Orthop Relat Res 2006;446:83-92.
Lotke PA, Carolan GF, Puri N. Impaction Grafting for Bone Defects in Revision Total Knee Arthroplasty. Clin Orthop Relat Res 2006;446:99-103.
Toms AD, Barker RL, Jones RS, Kuiper JH. Impaction Bone- Grafting in Revision Joint Replacement Surgery. J Bone Joint Surg Am 2004;86(9):2050-2060.
Zimmermann G, Moghaddam A. Allograft bone matrix versus synthetic bone graft substitutes. Injury 2011;42(Suppl 2):S16-21.
Malhotra A, Pelletier MH, Yu Y, Walsh WR. Can plateletrich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes. Arch Orthop Trauma Surg 2013;133(2):153-165.
Kassolis JD, Rosen PS, Reynolds MA. Alveolar Ridge and Sinus Augmentation Utilizing Platelet-Rich Plasma in Combination with Freeze-Dried Bone Allograft: Case Series. J Periodontol 2000;71(10):1654-1661.
Anitua E. The Use of Plasma-rich Growth Factors (PRGF) in Oral Surgery. Pract Proced Aesthet Dent 2001;13(6):487- 493.
Dallari D, Savarino L, Stagni C, Cenni E, Cenacchi A, Fornasari PM, et al. Enhanced Tibial Osteotomy Healing with Use of Bone Grafts Supplemented with Platelet Gel or Platelet Gel and Bone Marrow Stromal Cells. J Bone Joint Surg Am 2007;89(11):2413-2420.
Hollinger JO, Hart CE, Hirsch SN, Lynch S, Friedlaender GE. Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications. J Bone Joint Surg Am 2008;90(Suppl 1):48-54.
Peidro L, Segur JM, Poggio D, de Retana PF. Use of freezedried bone allograft with platelet-derived growth factor for revision of a glenoid component. J Bone Joint Surg Br 2006;88(9):1228-1231.
Savarino L, Cenni E, Tarabusi C, Dallari D, Stagni C, Cenacchi A, et al. Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: A standaridized methodology in patients with tibial osteotomy for genu varus. J Biomed Mater Res B Appl, Biomater 2006;76B(2):364-372.
Jensen TB, Rahbek O, Overgaard S, Søballe K. Platelet rich plasma and fresh frozen bone allograft as enhancement of implant fixation. An experimental study in dogs. J Orthop Res 2004;22(3):653-658.
Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal fusion. Bone 1999;25(2 [Suppl 1]):47S-50S.
Engh GA, Ammeen DJ. Classification and Preoperative Radiographic Evaluation: Knee. Orthop Clin North Am 1998;29(2):205-217.
Robertson DD, Mintzer CM, Weissman BN, Ewald FC, Le- Boff M, Spector M. Distal loss of femoral bone following total knee arthroplasty. Measurement with visual and computer-processing of roentenograms and dual-energy x-ray absorptiometry. J Bone Joint Surg Am 1994;76(1):66- 76.
Soininvaara T, Kröger H, Jurvelin JS, Miettinen H, Suomalainen O, Alhava E. Measurement of Bone Density Around Total Knee Arthroplasty Using Fan-Beam Dual Energy X-ray Absorptiometry. Calcif Tissue Int 2000;67(3):267-272.
Sacchetti GM, Ghisellini F, Brambilla M, De Consoli A, Fornara P, Rizzo E, et al. Quantitative Scintigraphic Evaluation of Total Knee Arthroplasties: A Feasibility Study. Clin Orthop Relat Res 1996;325:181-189.
Whiteside LA, Viganò R. Young and Heavy Patients with a Cementless TKA Do As Older and Ligthweight Patients. Clin Orthop Relat Res 2007;464:93-98.
Gioe TJ, Novak C, Sinner P, Ma W, Mehle S. Knee Arthroplasty in the Young Patient: Survival in a Community Registry. Clin Orthop Relat Res 2007;464:83-87.
Baré J, MacDonald SJ, Bourne RB. Preoperative Evaluations in Revision Total Knee Arthroplasty. Clin Orthop Relat Res 2006;446:40-44.
Engh GA, Ammeen DJ. Bone loss with revision total knee arthroplasty: defect classification and alternatives for reconstruction. Instr Course Lect 1999;48:167-175.
Anitua E. Plasma Rich in Growth Factors: Preliminary Results of Use in the Preparation of Future Sites for Implants. Int J Oral Maxillofac Implants 1999;14(4):529-535.
Habibovic P, de Groot K. Osteoinductive biomaterials –properties and relevance in bone repair. J Tissue Eng Regen Med 2007;1(1):25-32.
Wilkins RM. Unicameral Bone Cyst. J Am Acad Orthop Surg 2000;8(4):217-224.
Robertson DD, Mintzer CM, Weissman BN, Ewald FC, Le- Boff M, Spector M. Distal loss of femoral bone following total knee arthroplasy. Measurement with visual and computer-processing of roentenograms and dual-energy x-ray absorptiometry. J Bone Joint Surg Am 1994;76(1):66- 76.
Trevisan C, Bigoni M, Denti M, Marinoni EC, Ortolani S. Bone Assessment after Total Knee Arthroplasty by Dual-Energy Xray Absorptiometry: Analysis Protocol and Reproducibility. Clacif Tissue Int 1998;62(4):359-361.
Venesmaa PK, Kröger HPJ, Miettinen HJA, Jurvelin JS, Suomalainen OT, Alhava EM. Monitoring of Periprosthetic BMD After Uncemented Total Hip Arthroplasty with Dual-Energy X-ray Absorptiometry –A 3 Years Follow-Up Study. J Bone Miner Res 2001;16(6):1056-1061.
Peerbooms JC, Colaris JW, Hakkert AA, Van Appeldorn M, Brujin DJ, Den Oudsten BL, et al. No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study. Int Orthop 2012;36(10):2113-2119.
Dallari D, Fini M, Stagni C, Torricelli P, Nicoli Aldini N, Giavaresi G, et al. In vivo study on the healing of bone defects treated with bone marrow stromal cells, plateletrich plasma, and freeze-dried bone allografts, alone and in combination. J Orthop Res 2006;24(5):877-888.
Hakimi M, Jungbluth P, Sager M, Betsch M, Herten M, Becker J, et al. Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs. Injury 2010;41(7):717-723.
Mooren RE, Merkx MA, Bronkhorst EM, Jansen JA, Stoelinga PJ. The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats. Int J Oral Maxillofac Surg 2007;36(7):626-631.
Mooren R, Dankers A, Merkx M, Bronkhorst W, Jansen J, Stoelinga P. The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss®: an experimental study in goats. Int J Oral Maxillofac Surg 2010;39(4):371-378.
Kanthan SR, Kavitha G, Addi S, Choon D, Kamarul T. Plateletrich plasma (PRP) enhances bone healing in non-united critical-sized defects: A preliminary study involving rabbit models. Injury 2011;42(8):782-789.
Nather A, Wong K, David V, Pereira BP. Allografts with autogenous platelet-rich plasma for tibial defect reconstruction: a rabbit study. J Orthop Surg (Hong Kong) 2012;20(3):375- 380.
Bielecki T, Cieslik-Bielecka A, Zelawski M, Mikusek W. A side-effect induced by the combination of a demineralized freeze-dried bone allograft and leucocyte and platelet-rich plasma during treatment for large bone cysts: A 4-year follow-up clinical study. Transfus Apher Sci 2012;47(2):133- 138.
Wei Lc, Lei Gh, Sheng P, Gao SG, Xu M, Jiang W, et al. Efficacy of platelet-rich plasma combined with allograft bone in the management of displaced intra-articular calcaneal fractures: A prospective cohort study. J Orthop Res 2012;30(10):1570-1576.