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ISSN 0016-3813 (Impreso)

2003, Número 4

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Gac Med Mex 2003; 139 (4)


Migraña. Una revisión de la fisiopatogenia y alternativa terepéutica futura.

Millán-Guerrero RO, Pineda-Lucatero AG, Pacheco-Carrasco MF

Idioma: Español
Referencias bibliográficas: 58
Paginas: 377-380
Archivo PDF: 67.91 Kb.


RESUMEN

Este trabajo contempla descubrimientos recientes sobre la fisiopatogenia de la migraña, enfocándose a la combinación de eventos que se suceden en secuencia para originar la migraña. Se revisaron datos actuales sobre sustancia P, péptido intestinal vasoactivo, histamina, receptores H1, H3 y agonista de los receptores H3; todos ellos neuromoduladores que se encuentran en íntima relación con la migraña. Se expone el tratamiento que se recomienda para migraña y el motivo del fracaso de la terapéutica actual, que con dificultad alcanza el 70% de eficacia. Se contempla el futuro del tratamiento para migraña el cual deberá estar dirigido hacia la búsqueda de fármacos que interaccionen directamente con estos neuromoduladores para poder ofrecer a los pacientes con migraña, medicamentos con mejor eficacia y mínimos efectos indeseables.


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