Moreno-Carrillo A, Pulido-Arenas J, Bejarano-Zuleta A

Idioma: Español
Referencias bibliográficas: 50
Paginas: 56-63
Archivo PDF: 480.29 Kb.

RESUMEN

Los concentrados de complejo protrombínico son compuestos derivados del plasma que contienen los factores de coagulación dependientes de la vitamina K. Se desarrollaron en 1950 como fuente del factor IX para el tratamiento de la hemofilia B y su principal indicación actualmente es la reversión de los efectos de los anticoagulantes orales tipo antagonistas de la vitamina K en situaciones de urgencia. Otras indicaciones de su administración son: terapia de reemplazo de los factores II y X en ciertas deficiencias congénitas y adquiridas, coagulopatía asociada con enfermedad hepática severa, tratamiento de complicaciones hemorrágicas masivas perioperatorias, traumatismo en pacientes anticoagulados y coagulopatías por sepsis.

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