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2013, Número 1

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Rev Hosp Jua Mex 2013; 80 (1)


Biotransformación y efecto del diltiazem en la pared intestinal

Rodríguez-Wong U, Ocharán-Hernández ME, Toscano-Garibay J, Garrido-Acosta O, Anguiano-Robledo L, Cruz-Rico J, Ruiz-Pérez NJ, Sánchez-Navarrete J, Pérez-Cruz E, Montes-Vera MR

Idioma: Español
Referencias bibliográficas: 37
Paginas: 34-40
Archivo PDF: 340.55 Kb.


RESUMEN

El diltiazem es un calcio antagonista que inhibe tanto los canales lentos de calcio con actividad en el músculo liso vascular y el músculo cardiaco, así como la liberación de calcio almacenado en el retículo sarcoplásmico. No obstante que el hígado se reconoce como el mayor sitio responsable del metabolismo de este fármaco, existe poca información respecto al papel de otros órganos en la biotransformación del diltiazem y de sus metabolitos. La presencia de citocromo P-450 y otras enzimas biotransformadoras en muchos otros órganos sugiere que los tejidos extrahepáticos pueden contribuir a la biotransformación de sustratos endógenos y exógenos. Algunos estudios in vitro han demostrado que las isoenzimas del citocromo P-450 necesarias para el metabolismo del diltiazem y de sus metabolitos se encuentran presentes no sólo en el hígado, sino también en órganos como el intestino, riñón y pulmones.


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