Ruíz-Morales JA, Cruz-Medina CS, Pérez-García M, Campos-Gutiérrez MÁ, del Campo-Martínez M, Olaya-Vargas A

Idioma: Español
Referencias bibliográficas: 25
Paginas: 348-352
Archivo PDF: 353.42 Kb.

RESUMEN

La gammaglobulia intravenosa (GGIV) contiene un concentrado de anticuerpos IgG obtenidos de miles de donadores y se ha utilizado como terapia en varias enfermedades, como: inmunodeficiencias primarias, enfermedades autoinmunitarias y enfermedad de Kawasaki. En el área de trasplante se ha usado la GGIV en el tratamiento de infecciones virales, enfermedad injerto contra huésped y en la sensibilización por anticuerpos antidonador. Estos últimos son un factor de riesgo importante para el rechazo agudo mediado por anticuerpos en el trasplante renal y para la falla de injerto durante el trasplante de células progenitoras hematopoyéticas. El uso de GGIV como tratamiento para la sensibilización de los pacientes que se someterán a trasplante renal o de progenitores hematopoyéticos reduce el riesgo de rechazo agudo del injerto.

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