Duarte MJ, Díaz MS, Vargas GRB, Rubio GJ, Lee Eng CVE

Idioma: Español
Referencias bibliográficas: 44
Paginas: 172-182
Archivo PDF: 135.20 Kb.

RESUMEN

A pesar de los espectaculares avances en la tecnología de soporte vital, el manejo de pacientes con sepsis severa continúa siendo muy costoso debido a su elevada morbi-mortalidad. La sepsis severa se asocia a falla multiorgánica, siendo la causa principal de muerte en las unidades de terapia intensiva. En el síndrome de sepsis grave se activan diversas vías que provocan una inflamación sistémica. Hace aproximadamente 60 años se utilizaron dosis altas de esteroides con la esperanza de resolver este problema, sin embargo su empleo declinó debido a su poca utilidad y a sus efectos colaterales. Recientemente se están utilizando de nuevo a dosis más bajas en el tratamiento de la disfunción suprarrenal y del choque séptico.

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