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Antes Revista del Instituto Nacional de Enfermedades Respiratorias

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2013, Número 3

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Neumol Cir Torax 2013; 72 (3)


Modulación de la síntesis de interferones en la infección por paramixovirus

Galván-Morale MÁ, Sarmiento-Silva RE, Manjarrez-Zavala ME

Idioma: Español
Referencias bibliográficas: 87
Paginas: 241-255
Archivo PDF: 424.91 Kb.


RESUMEN

Los virus: 1) sincitial respiratorio, 2) sarampión, 3) parainfluenza y 4) parotiditis, son los virus de la familia Paramixoviridae con mayor incidencia en el hombre. Estos virus son inductores eficientes de la producción de interferón de tipo I y II (IFN-α/β y γ), y en los últimos años ha quedado claro que éstos comparten proteínas que actúan en la regulación del sistema inmune. La mayoría de los paramixovirus codifican para proteínas que activan mecanismos inhibidores de la producción de los IFNs, disminuyendo la eficiencia de la respuesta inmunológica. En este artículo se mencionan eventos que llevan a la producción de los IFNs mediada por los receptores de reconocimiento de patrones (PRR’s) que a su vez son activados por patrones moleculares asociados a patógenos o PAMPs de cada uno de estos virus. Se describe cómo interaccionan las diferentes proteínas virales (P/V/C, G y NS1 y 2) con su célula blanco y se describe cómo estos cuatro paramixovirus limitan la producción de PAMPs e inhiben las respuestas celulares al interferir con las actividades de los PRR’s, MDA5 y RIG-I, inhibiendo así a diversos componentes de la vía de señalización en la inducción de los IFNs.


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