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2013, Número 5

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Gac Med Mex 2013; 149 (5)


Respuesta inmune e inmunopatogénesis en las infecciones con el virus del dengue

Castro-Mussot ME, Machain-Williams C, Loroño-Pino MA, Salazar MI

Idioma: Español
Referencias bibliográficas: 100
Paginas: 531-540
Archivo PDF: 148.94 Kb.


RESUMEN

La comprensión de los mecanismos, tanto de inducción de la inmunidad protectora como de la inmunopatogénesis en el dengue, es aún insuficiente. El balance entre los efectores de la respuesta inmune es central tanto en la protección como en la patogénesis, e impacta en la gravedad de la enfermedad. Aquí revisamos los elementos de la respuesta inmune que participan en las infecciones con el virus del dengue (DENV) y se contrastan los niveles de algunos de estos efectores en la fiebre por dengue (FD) y en la fiebre hemorrágica por dengue (FHD)/síndrome de choque por dengue (SCD). Está claro que varios componentes de la respuesta inmune se encuentran aumentados o desregulados en los casos graves de dengue y que contribuyen a la inmunopatogénesis. Finalmente, es importante destacar que el mecanismo global por el cual la función protectora de la respuesta inmune se altera y contribuye a la patogénesis en las formas graves de la enfermedad permanece sin dilucidarse completamente.


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