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2013, Número 5

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Gac Med Mex 2013; 149 (5)


El factor de necrosis tumoral α (TNF-α) en las enfermedades cardiovasculares: biología molecular y genética

Fragoso LJM, Sierra MM, Vargas AG, Barrios RA, Ramírez BJ

Idioma: Español
Referencias bibliográficas: 95
Paginas: 521-530
Archivo PDF: 231.71 Kb.


RESUMEN

Las enfermedades cardiovasculares representan la primera causa de morbimortalidad en el mundo y la principal problemática de salud pública a nivel global. En 1997, este grupo de enfermedades causó el 41% de las muertes en EE.UU. Se ha reportado que cerca de 60 millones de personas que viven en EE.UU. tienen algún tipo de enfermedad cardiovascular. Estas entidades son condiciones crónicas iniciadas por la desregulación en la respuesta inmunológica. El gen TNF-α y su producto proteico: la citocina multifuncional TNF-α, juegan un papel determinante en el inicio, desarrollo, susceptibilidad, gravedad y respuesta al tratamiento, etc., en la enfermedad arterial coronaria (EAC). Esta revisión se enfoca en presentar al lector el rol biológico del TNF-α en el inicio y progresión de la disfunción endotelial, aterosclerosis y ruptura de la placa aterosclerótica, y cómo la variabilidad genética del TNF-α se relaciona con la susceptibilidad, la gravedad y la respuesta al tratamiento en la EAC, el infarto agudo de miocardio (IAM) con y sin elevación del segmento ST, la angina inestable (AI) y la reestenosis coronaria.


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