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2013, Número 2

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Residente 2013; 8 (2)


Modificaciones en los títulos de anticuerpos antipéptidos cíclicos citrulinados (ANTI-CCP) con el uso de agentes antifactor de necrosis tumoral alfa (ANTI-TNF) en pacientes con artritis reumatoide

Loaiza-Cárdenas C, Murillo-Vázquez JD, Pérez-Guerrero EE, Bonilla-Lara D, Aguilar-Chávez ÉA, González-López L

Idioma: Español
Referencias bibliográficas: 53
Paginas: 70-80
Archivo PDF: 284.36 Kb.


RESUMEN

Los anticuerpos antipéptidos cíclicos citrulinados son un tipo de autoanticuerpo, los cuales están dirigidos contra las proteínas citrulinadas en los pacientes con artritis reumatoide. Los anticuerpos antipéptidos cíclicos citrulinados se pueden encontrar como títulos séricos elevados en etapas tempranas de la enfermedad y están asociados a la artritis erosiva. El factor de necrosis tumoral está implicado en la patogénesis del proceso inflamatorio en pacientes con artritis reumatoide y es un blanco terapéutico para lograr un mejor control de la enfermedad. Al momento actual, una de las terapias más efectivas para lograr un control de la artritis reumatoide incluye a los agentes antifactor de necrosis tumoral, pero su efecto clínico sobre los autoanticuerpos en artritis reumatoide no está del todo identificado. Esta revisión evalúa la evidencia conocida del efecto del uso de agentes antifactor de necrosis tumoral en los títulos séricos de anticuerpos antipéptidos cíclicos citrulinados en estudios longitudinales.


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