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Academia Mexicana de Neurología, A.C.

2011, Número 4

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Rev Mex Neuroci 2011; 12 (4)


Encefalitis sinápticas autoinmunes

Santiesteban-Velázquez NJ, Merayo-Llanes RY

Idioma: Español
Referencias bibliográficas: 26
Paginas: 204-209
Archivo PDF: 143.63 Kb.


RESUMEN

Recientemente han sido descritos síndromes con respuesta al tratamiento inmunomodulador que afectan la función del hipocampo y de la corteza, demostrándose su asociación con auto-anticuerpos contra antígenos sinápticos, particularmente para los receptores del glutamato y receptores GABA-B. Estos trastornos sinápticos pueden dar lugar a una amplia variedad de síntomas, incluyendo psicosis, trastornos del movimiento, déficit de memoria a corto plazo, y convulsiones refractarias. En algunos casos, estos trastornos se producen como una manifestación paraneoplásica de un cáncer asociado. Estos síntomas a menudo mejoran dramáticamente después de la resección del tumor o la inmunoterapia. Además, para algunos síndromes, la presencia de un tumor no necesariamente indica un mal pronóstico. En todos los síndromes, el déficit puede ser reversible a pesar de la duración o gravedad de los síntomas.


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