2013, Número 2
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Rev Med Inst Mex Seguro Soc 2013; 51 (2)
Relación entre las enfermedades tiroideas autoinmunes y las del tejido conectivo
Barragán-Garfias JA, Zárate A
Idioma: Español
Referencias bibliográficas: 43
Paginas: e1-e5
Archivo PDF: 63.87 Kb.
RESUMEN
Si bien la función fisiológica del sistema inmunitario consiste en la defensa contra los microorganismos infecciosos,
en ocasiones hay pérdida de la autotolerancia, que
deriva en el desconocimiento de los autoantígenos. Las
tiroidopatías son las enfermedades autoinmunes más
comunes relacionadas con las glándulas exocrinas, a
su vez las tiroideas autoinmunes órgano-específicas
más frecuentes son la enfermedad de Graves-Basedow
y la tiroiditis de Hashimoto. Se ha observado que
estas tienen una mayor prevalencia en pacientes con
enfermedades del tejido conectivo (autoinmunes sistémicas)
tales como el síndrome de Sjögren, artritis
reumatoide, el lupus eritematoso sistémico y las miopatías
sistémicas. De igual forma, se ha identifi cado
una mayor prevalencia de anticuerpos antinucleares y
de anticuerpos contra antígenos extraídos del núcleo
en pacientes con alguna enfermedad tiroidea autoinmune.
Dado el alto porcentaje de pacientes con enfermedades
tiroideas subclínicas, es recomendable que
en los pacientes con enfermedades del tejido conectivo
y datos de hipo o hipertiroidismo se solicite anticuerpos
antitiroglobulina y antiperoxidasa.
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