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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2011, Número 2

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Rev Invest Clin 2011; 63 (2)


Células troncales cancerosas

Schwarz-Cruz-y-Celis Á, Meléndez-Zajgla J

Idioma: Ingles.
Referencias bibliográficas: 46
Paginas: 179-186
Archivo PDF: 283.58 Kb.


RESUMEN

Existen dos teorías para explicar la progresión tumoral. La primera, llamada estocástica, plantea que cualquier célula dentro del tumor tiene la capacidad de formar y mantener la masa tumoral. La segunda, denominada jerárquica, plantea la existencia de un grupo de células con fenotipo troncal (stem), que de manera similar a los tejidos normales adultos, mantiene al tumor mediante la producción continua de progenie. Estas células troncales se encuentran dentro de un nicho particular y poseen mayor resistencia a fármacos y radioterapia, además de ser capaces de invadir y migrar a otros tejidos. La presente revisión trata de describir las células troncales cancerosas (CTC’s), las funciones de éstas dentro de un tumor, así como el conocimiento actual de las mismas.


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