2009, Número 2
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Rev Invest Clin 2009; 61 (2)
Datos poblacionales de cinco STRs de la serie INTERPOL en una población mestiza del Occidente de México
Quintero-Ramos A, Padilla-Gutiérrez JR, Hernández-Zaragosa G, Valle Y, Valdez-Velázquez LL, Olivares N, Rivas F
Idioma: Español
Referencias bibliográficas: 39
Paginas: 104-109
Archivo PDF: 99.35 Kb.
RESUMEN
Introducción. Las repeticiones cortas en tándem o STRs (
short tandem repeats), son los marcadores polimórficos más utilizados en genética forense y pruebas de parentesco. Las series de STRs más comunes son la serie CODIS del FBI y la de INTERPOL. Si bien se conocen estudios en relación con la primera serie, no existen hasta la fecha reportes en poblaciones mexicanas con marcadores del grupo de INTERPOL.
Objetivo. Describir las características genéticas y estimar los principales parámetros forenses de cinco STRs de la serie INTERPOL en una población mestiza del occidente de México.
Material y métodos. Se analizaron mediante PCR muestras de 100 voluntarios no emparentados entre sí, residentes en el estado de Jalisco, para los STRs F13B, D2S1338, FESFPS, Penta D y Penta E.
Resultados. Las proporciones genotípicas para los cinco STRs estuvieron de acuerdo con las expectativas de Hardy-Weinberg (p › 0.05). La heterozigocidad varió de 0.68 para el marcador FESFPS a 0.91 para el Penta E. El poder de discriminación (PD) y la probabilidad de exclusión (PE) estuvieron en los rangos 0.83-0.97 y 0.46-0.75, respectivamente. Para los cinco sistemas combinados se obtuvo un PE › 0.99143 y un PD › 0.99999.
Conclusiones. Los resultados contribuyen a establecer bases de datos representativos de la región, mismas que son útiles en las pruebas forenses y de parentesco basadas en los perfiles de ADN.
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