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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2008, Número 2

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Rev Invest Clin 2008; 60 (2)


Mecanismos de regulación de la síntesis y secreción de la gonadotropina coriónica humana (hCG) durante el embarazo

Barrera D, Chirinos M, García-Becerra R

Idioma: Español
Referencias bibliográficas: 63
Paginas: 124-132
Archivo PDF: 92.96 Kb.


RESUMEN

La gonadotropina coriónica humana (hCG) es una hormona proteica esencial para el desarrollo y sostenimiento de la gestación. La adecuada producción de la hCG es fundamental para que el embarazo llegue a término, ya que concentraciones anormales de la hormona han sido correlacionadas con anomalías como los abortos recurrentes y la preeclampsia. La regulación de la producción de la hCG implica diversas moléculas que emplean diferentes vías de señalización para mediar sus efectos sobre las concentraciones de hCG, lo cual ha dificultado el establecimiento de los mecanismos involucrados en su producción. En este trabajo se hace una revisión crítica de los hallazgos más relevantes relacionados con la producción de la hCG y su función durante el embarazo con el objeto de comprender ciertas patologías relacionadas y tratarlas de la manera más apropiada.


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