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2000, Número 6

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Arch Cardiol Mex 2000; 70 (6)


La terapéutica metabólica con glucosa-insulina-potasio. Bosquejo histórico

Micheli A

Idioma: Español
Referencias bibliográficas: 62
Paginas: 609-615
Archivo PDF: 132.17 Kb.


FRAGMENTO

El corazón de los animales de sangre caliente puede tolerar la hipoxia sólo por breve tiempo, del orden de un minuto, sin sufrir alteraciones metabólicas ni funcionales. Un periodo de hipoxia más prolongado altera sensiblemente la función cardiaca. El corazón isquémico, y por ende hipóxico, agota rápidamente sus reservas energéticas porque la resíntesis de ATP resulta más lenta y más escasa. En tales condiciones, el ATP se produce casi exclusivamente por la glucólisis y ocurre una mayor síntesis de triglicéridos. La reducida concentración de O2 en el miocardio afectado se aprovechó a su tiempo para determinar, con inyección de azul Evans, la extensión del área de infarto en animales de laboratorio. En éstos, unos 15 min después de la oclusión de la arteria coronaria correspondiente, el ATP desaparece casi por completo debido a las alteraciones de los procesos de la fosforilación oxidativa.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Núñez R, Calva E, Briones E, López Soriano F: Cambios en los nucleótidos de nicotinamida adenina tisulares durante el infarto experimental del miocardio. Memorias del VI Congreso Mexicano de Cardiología. México, 1969: 160-161.

  2. Braasch W, Gudbjarnason S, Puri PS, Ravens KG, Bing RJ: Early changes in energy metabolism in the myocardium following acute coronary artery occlusion in anesthetized dogs. Circ Res 1968; 23: 429-438.

  3. 2a. De Micheli A: Las bases racionales del tratamiento polarizante en el infarto del miocardio. Arch Inst Cardiol Mex 1969; 39: 713-731.

  4. Calva E, Trillo A, Núñez R, Aoki K, Ariza D: Relaciones entre los cambios bioquímicos y ultraestructurales del corazón con infarto experimental. Arch Inst Cardiol Mex 1969; 39: 696-712.

  5. Gudbjarnason S, Braasch W, Cowan C, Bing RJ: Metabolism of infarcted heart muscle during tissue repair. Am J Cardiol 1968; 22: 360-369.

  6. Manning JP, Pensinger RR, Fehn PA: Cardiac alkaline and acid phosphatase activity and potassium concentration in dog with acute myocardial infarction. Cardiovasc Res 1968; 2: 308-313.

  7. Ravens KG, Gudbjarnason S: Changes in the activities of lysosomal enzymes in infarcted canine heart muscle. Circ Res 1969; 24: 851-856.

  8. Yamamura Y: Energy metabolism in myocardium. Jpn Circ J 1968; 32: 1801-1804.

  9. Gudbjarnason S, De Schryver C, Chiba C, Yamanaka J, Bing RJ: Protein and nucleic acid synthesis during the reparative process following myocardial infarction. Circ Res 1964; 15: 320-326.

  10. Flower R: Glucocorticoids, phospholipase A2 and inflammation. Trends Pharmacol Sci 1981; 2: 186-189.

  11. Larcan A, Huriet C: L’électrocardiogramme dysmétabolique. París. Ed. Masson & Cie, 1959.

  12. Olson RE: Metabolic interventions in the treatment of infarcting myocardium. Circulation 1969; 40(Suppl 4): 195-201.

  13. De Micheli A: Enfoque racional de ciertos aspectos diagnósticos y terapéuticos del infarto del miocardio. Arch Inst Cardiol Mex 1971; 41: 340-356.

  14. Janusckevicius ZI, Blujas II, Vitkus AS: Lecenie infarkta miokarda poljarizujutscei i fibrinolizinpoljarizutscei smesjani. (Tratamiento del infarto del miocardio con la solución polarizante y la mezcla fibrinolisin-polarizante). Kardiologiia 1966; 6(4): 48-53

  15. Smith AE, Luten D: Study of glucose therapy in heart failure in advanced cardiac disease. Am Heart J 1934; 9: 437-446.

  16. Kisthinios N: Le traitement des cardiopathies par l’association sucre-insuline. París. JB Baillière et Fils, 1933.

  17. Olascoaga JQ: Principales acciones fisiológicas de la combinación azúcar-insulina en terapéutica cardiaca. (Tesis recepcional). México. UNAM, 1933.

  18. Iseri LT, Alexander LC, Mc Caughey RS, Bayle AJ, Myers GB: Water and electrolyte content of cardiac and skeletal muscle in heart failure and myocardial infarction. Am Heart J 1952; 43: 215-227.

  19. Hazard J: Le potassium en biologie et en thérapeutique. París. Ed. Exp Scient Franç, 1954.

  20. McAllen PM: Myocardial changes occurring in potassium deficiency. Br Heart J 1955; 17: 5-14.

  21. Selye H: The chemical prevention of cardiac necrosis. Nueva York. The Ronald Press Co, 1958.

  22. Michon P, Larcan A, Gaucher P: Potassium et énergétique myocardique. Sem Hôp Paris 1959; 35: 3289.

  23. Sodi Pallares D, de Micheli A: Un tentativo di reintegrazione ionica cellulare in alcune malattie cardiovascolari. Atti Acc Med Lombarda 1962; 17(4): 509-519.

  24. Haneda T, Ganz W, Lee T, Katz J: Reduction of myocardial oxygen demand by glucose-insulin-potassium (GIK). Circulation 1974; 50 (Suppl. III): 102.

  25. Opie LH: Metabolism of free fatty acids, glucose, and catecholamines in acute myocardial infarction. Am J Cardiol 1975; 36: 938-953.

  26. Opie LH, Bricknel OL: Role of glycolitic flux in effect of glucose in decreasing fatty acid-induced decrease of lactate dehydrogenase from isolated coronary ligated rat heart. Cardiovasc Res 1979; 13: 693-702.

  27. De Micheli A, Medrano GA, Sodi Pallares D: Efectos de algunas soluciones electrolíticas sobre la evolución electrocardiográfica del infarto experimental agudo del miocardio. Arch Inst Cardiol Mex 1963; 33: 567-580.

  28. Sodi Pallares D, Bisteni A, Medrano GA, Testelli MR, de Micheli A: The polarizing treatment of acute myocardial infarction: Possibility of its use in other cardiovascular conditions. Dis Chest 1963; 43: 424-432.

  29. Calva E, Mújica A, Bisteni A, Sodi Pallares D: Oxidative phosphorylation in cardiac infarct. Effect of glucose-KCl-insulin solution. Am J Physiol 1965; 209: 375-380.

  30. Calva E, Mújica A, Núñez R, Aoki K, Bisteni A, Sodi Pallares D: Mitochondrial biochemical changes and glucose-KCl-insulin solution in cardiac infarct. Am J Physiol 1966; 211: 71-76.

  31. Sybers HD, Maroko PR, Ashraf M, Libby P, Braunwald E: The effect of glucose-insulin-potassium on cardiac ultrastructures following acute experimental coronary occlusion. Am J Pathol 1973; 70: 401-420.

  32. Prasad K, Callaghan JC: Effects of glucose metabolism on the transmembrane action potential and contraction of human papillary muscle during surgical anoxia. Ann Thorac Surg 1969; 7: 571-580.

  33. Prasad K, Callaghan JC: Electrophysiologic basis of use of a polarizing solution in the treatment of myocardial infarction. Clin Pharmacol Ther 1971; 12: 666-675.

  34. De Micheli A, Medrano GA, Villarreal A, Sodi Pallares D: Superiority of the glucose-potassium-insulin solution over the glucose, glucose-insulin and glucose-potassium solutions in acute experimental digitalis intoxication. Acta Cardiol 1971; 26(4): 400-417.

  35. De Micheli A, Medrano GA, Villarreal A, Sodi Pallares D: Observaciones sobre la intoxicación quinidínica aguda experimental. Arch Inst Cardiol Mex 1972; 42(4): 580-588.

  36. De micheli A, Medrano GA, Villarreal A, Sodi Pallares D: Efecto protector de la solución glucosa-insulina-potasio en el daño miocárdico producido por emetina. Arch Inst Cardiol Mex 1975; 45(4): 469-486.

  37. Murphy ML, Bulloch RT, Pearce MB: The correlation of metabolic and ultrastructural changes in emetine myocardial toxicity. Am Heart J 1974; 87: 105-108.

  38. De Micheli A, Medrano GA, Testelli M, Sodi Pallares D: L’action de certaines substances chimiques sur l’électrogramme, l’électrocardiogramme et la courbe de tension artérielle chez le chien. Mal Cardiovasc 1963; 4: 607-649.

  39. Hess ML, Okabe E, Poland J, Werner M, Stewart JR, Greenfield LJ: Glucose, insulin, potassium protection during the course of hypothermic global ischemia and reperfusion; a new proposed mechanism by the scavenging of free radicals. J Cardiovasc Pharmacol 1983; 5: 35-43.

  40. Doenst T, Richwine RT, Bray MS, Gary W, Goodwin GW, Frazier OH, et al: Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg 1999; 67(6): 1682-1688.

  41. Lal HB, Caroli RK: Observations on 400 cases of acute myocardial infarction treated with insulin-potassium and dextrose infusions. Ind J Med Res 1968; 56 (Suppl): 1120.

  42. Sodi Pallares D, de Micheli A, Medrano G, Fishleder B, Bisteni A, Friedland C, Testelli M: Effets sur l’électrocardiogramme de la solution glucose-insuline-potassium au cours de l’insuffisance coronarienne aiguë et chronique. Mal Cardiovasc 1962; 3(1): 41-79.

  43. Sodi Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, de Micheli A: Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol 1962; 9(2): 166-181.

  44. Mittra B: Use of potassium, glucose and insulin in the treatment of myocardial infarction. Prog Cardiovasc Dis 1968; 10: 529-544.

  45. Rogers WJ, Russell RO Jr, McDaniel HG, Rackley CE: Effects of glucose-insulin-potassium infusion on myocardial metabolism in man. Am J Cardiol 1977; 40: 421-428.

  46. Rogers WJ, Segall PH, McDaniel HG, Mantle JA, Russell RO Jr, Rackley CE: Prospective randomized trial of glucose-insulin-potassium in acute myocardial infarction. Effects on myocardial hemodynamics, substrates and rhythm. Am J Cardiol 1979; 43: 801-809.

  47. Mantle JA, Rogers WJ, Smith LR, McDaniel HG, Papapietro SE, Russell RO Jr, Rackley CE: Clinical effects of glucose-insulin-potassium on left ventricular function in acute myocardial infarction. Results from a randomized clinical trial. Am Heart J 1981; 102: 313-324.

  48. Taegtmeyer H, Goodwin GW, Doenst T, Frazier OH: Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol 1997; 80: 3A-10A.

  49. 47a. Fath-Ordoubadi F, Beatt KJ: Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation 1997; 96: 1152-1156.

  50. Díaz R, Paolasso EA, Piegas LS, Tajer CD, Gil Moreno M, Corvalán R, et al: Metabolic modulation of acute myocardial infarction. The ECLA glucose-insulin-potassium pilot trial. Circulation 1998; 98: 2227-2234.

  51. Apstein CS: Glucose-insulin-potassium for acute myocardial infarction. Remarkable results from a new prospective, randomized trial. Circulation 1998; 98: 2223-2226.

  52. Marano L, Bestetti A, Lomuscio A, Tagliabue L, Castini D, Torricone D, et al: Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction. Acta Cardiol 2000; 55(1): 9-15.

  53. Moffitt EA, Rosevear JW, Molnar GD, McGoon DC: Effect of glucose, insulin, potassium solution on ketosis following cardiac surgery. Anesth Analg 1971; 50: 291-297.

  54. Moffitt EA, Rosevear JW, McGoon DC: Myocardial metabolism in children having open-heart surgery. JAMA 1970; 211: 1518-1524.

  55. Moffitt EA, Rosevear JW, McGoon DC: Myocardial metabolism during and after mitral valve replacement. Ann Thorac Surg 1970; 10: 169-179.

  56. Girard C, Quentin P, bouvier H, Blanc P, Bastien O, Lehot JJ, et al: Glucose and insulin supply before cardiopulmonary bypass in cardiac surgery: a double-blind study. Ann Thorac Surg 1992; 54: 259-263.

  57. Besogul Y, Tunerir S, Asian R, Isiksoy S, Colak O, Kural T: Clinical, biochemical and histochemical assessment of pretreatment with glucose-insulin-potassium for patients undergoing mitral valve replacement in the third and fourth functional groups of the New York Heart Association. Cardiovasc Surg 1999; 7(6): 645-650.

  58. Dainese L, Polvani GL, Fumero A, Spirito R, Alamanni F, Agrifoglio M, et al: Glucosa-insulina-potassio (GIK) nella riduzione dell’ischemia miocardica acuta dopo intervento di bypass aorto-coronario. G Ital Cardiol 1999; 29(5): 575-579.

  59. Harold L, Lazar MD: Enhanced preservation of acutely ischemic myocardium using glucose-insulin-potassium solution. J Cardiovasc Surg 1994; 9(Suppl): 474-478.

  60. Apstein CS, Opie LH: Glucose-insulin-potassium (GIK) for acute myocardial infarction: a negative study with a positive value. Cardiovasc Drugs Ther 1999; 13(3): 185-189.

  61. Ceremuzynski L, budoj A, Czapiel A, Burzykowski T, Achremczyk P, Smielakkorombel W, et al: Low-dose glucose-insulin-potassium is ineffective in acute myocardial infarction: Results of a randomized multicenter Pol-GIK trial. Cardiovasc Drugs Ther 1999; 13(3): 191-200.

  62. Michaels AD, Gibson CM, Barron HV: Microvascular dysfunction in acute myocardial infarction: Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon. Am J Cardiol 2000; 85: 50B-60B.




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