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2011, Número 1

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Evid Med Invest Salud 2011; 4 (1)


E-cadherina: Pieza clave en la transformación neoplásica

Günther J, Pedernera-Astegiano E

Idioma: Español
Referencias bibliográficas: 53
Paginas: 15-20
Archivo PDF: 203.45 Kb.


RESUMEN

Las cadherinas son una superfamilia de glucoproteínas transmembranales que intervienen en la adhesión célula-célula. Las clásicas incluyen la E-cadherina y N-cadherina. La expresión y función de la E-cadherina es esencial para muchos procesos durante el desarrollo embrionario, como la polarización celular y diferenciación epitelial. Por otro lado se ha descubierto una importancia enorme en la tumorgénesis. La pérdida de la adhesión celular mediada por E-cadherina es un evento inicial de la transición epitelio-mesénquima (TEM), la cual se correlaciona con un incremento de invasión y metástasis en diversos cánceres humanos. Se ha demostrado que Snail es el promotor más importante de la TEM, inhibiendo la expresión de la E-cadherina y otros factores reguladores de la TEM. Por ello se considera a E-cadherina una pieza clave en la transformación neoplásica.


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