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2000, Número 2

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Arch Cardiol Mex 2000; 70 (2)


Liberación de óxido nítrico inducida por el flujo sanguíneo. Novedades y perspectivas de investigación

Suárez MPJ

Idioma: Español
Referencias bibliográficas: 55
Paginas: 197-202
Archivo PDF: 153.04 Kb.


RESUMEN

El ambiente mecánico de las células de mamífero está definido por interacciones complejas entre fuerzas gravitacionales, fuerzas locales generadas por el aire, presión hidrostática y movimiento, así como la tensión intracelular derivada de la organización de los elementos del citoesqueleto. Con la excepción de la sangre, los componentes de tejidos de vertebrados desarrollan tensión por interacciones físicas con la matriz extracelular y células vecinas. La importancia fundamental de esto se refleja en la expresión dependiente de adhesión de la diferenciación celular normal, crecimiento y función. Las respuestas simples de organismos unicelulares a fuerzas externas han evolucionado en los mamíferos a sistemas sensoriales finos y sofisticados, así como respuestas adaptativas a cambios prolongados en el ambiente mecánico. En el sistema cardiovascular del mamífero, el endotelio presenta respuestas singulares a las fuerzas del flujo sanguíneo.


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