Triana-Martínez F, Gómez-Quiroz LE, Mina KF

Idioma: Español
Referencias bibliográficas: 26
Paginas: 136-144
Archivo PDF: 238.15 Kb.

RESUMEN

Proteostasis es el término que se ha ocupado para definir a la homeostasis proteínica dentro de la célula. Este concepto abarca el estudio de las proteínas de manera individual, desde su síntesis, ubicación celular y función, hasta su vida media y degradación. Sin embargo, la proteostasis también se enfoca en la actividad grupal de las proteínas, analizando cuales de ellas funcionan dentro de una red de trabajo. Cuando las proteínas interactúan como una red de trabajo, producen flujos de información a través de diversos componentes. La eficiente coordinación entre las proteínas que conforman el flujo de la información es esencial para el correcto funcionamiento y supervivencia de la célula.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Balch W, Morimoto R, Dillin A, Kelly J (2008) Adapting proteostasis for disease intervention. Science 319:916–919.

2. Roth DM, Balch W (2011) Modeling general proteostasis: proteome balance in health and Disease. Curr Op Cell Biol 23:126–134.

3. Powers E, Morimoto R, Dillin A, Kelly J, Balch W (2009) Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 78:959–991.

4. Ellis J, Minton A (2006) Protein aggregation in crowded environments. Biol Chem 387: 485–497.

5. Dill K, Ozkan S, Shell M, Weikl T (2008) The protein folding problem. Annu Rev Biophys 37:289–316.

6. Auer S, Miller M, Krivov S, Dobson C, Karplus M, Vendruscolo M (2007) Importance of metastable states in the free energy landscapes of polypeptide chains. Phys Rev Lett 99:178-184.

7. Elcock A (2006) Molecular simulations of cotranslational protein folding: fragment stabilities, folding cooperativity, and trapping in the ribosome. PLoS Comput Biol. 2, e98

8. Hartl U, Bracher A, Hayer-Hartl M (2011) Molecular chaperones in protein folding and proteostasis. Nature 475: 324-332.

9. Chakraborty K, Chatila M, Sinha J, Shi Q, Poschner C, Sikor M, Jiang G, Lamb C, Hartl U, Hayer-Hartl M (2010) Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell 142:112−122.

10. Tyedmers J, Mogk A, Bukau B (2010) Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol. 11: 777-788.

11. Baird N, Turnbull D, Johnson E (2006) Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem 281: 38675–38681.

12. Liu Y, Ye Y (2011) Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy. Cell Res 21:867-883.

13. Martínez A, Portero-Otin M, Pamplona R, Ferrer I (2010) Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol 20: 281-297.

14. Kroemer G, Mariño G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell. 40: 280-293.

15. Neves SR, Tsokas P, Sarkar A, Grace E, Rangamani P, Taubenfeld S, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R (2008) Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 133: 666-680.

16. Wang Y, Botvinick E, Zhao Y, Berns M, Usami S, Tsien RY, Chien S (2005) Visualizing the mechanical activation of Src. Nature 434:1040-1045.

17. Meyers J, Craig J, Odde D (2006). Potential for control of signaling pathways via cell size and shape. Curr Biol 16:1685-1693.

18. Craske ML, Fivaz M, Batada N, Meyer T (2005) Spines and neurite branches function as geometric attractors that enhance protein kinase C action. J Cell Biol 170: 1147-1158.

19. Easley D, Kleinberg J (2010) Networks, Crowds, and Markets—Reasoning About a Highly Connected World. New York, NY: Cambridge University Press.

20. Vidal M, Cusick M, Barabási AL (2011) Interactome networks and human disease. Cell 144: 986-998.

21. Rosvall M, Bergstrom CT (2007) Maps of random walks on complex networks reveal community structure. Proc Natl Acad Sci U S A 105: 1118-1123.

22. Corning P (1995) Synergy and self-organization in the evolution of complex systems. Systems Research, 12: 89–121.

23. Ivanović-Šašić AZ, Marković VM, Anić SR, Kolar-Anić LjZ, Cupić ŽD (2011) Structures of chaos in open reaction systems. Phys Chem Chem Phys 13: 20162-20171.

24. Von Delius M, Leigh DA (2011) Walking molecules. Chem Soc Rev 40: 3656-3676.

25. Kawaguchi Y, Kovacs J, McLaurin A, Vance JM, Ito A, Yao TP (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115: 727–738.

26. Davalos AR, Coppe JP; Campisi J, Desprez PY (2010) Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 29 :273–283.