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2010, Número 6

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Rev Med Inst Mex Seguro Soc 2010; 48 (6)


Respuesta inmune rápida contra la hepatitis B mediante esquema acelerado de vacunación intradérmica

Solórzano-Santos F, Pérez-de la Cruz L, Meléndez-Blanco SP, Álvarez-y Muñoz MT, Huerta-García GC, Miranda-Novales MG, Vázquez-Rosales G

Idioma: Español
Referencias bibliográficas: 30
Paginas: 603-606
Archivo PDF: 32.87 Kb.


RESUMEN

Objetivo: evaluar los niveles séricos de anticuerpos contra el virus de la hepatitis B en personal de salud que recibió un esquema acelerado por vía intradérmica con microdosis de la vacuna recombinante.
Métodos: estudio cuasiexperimental sin grupo control en trabajadores de la salud sanos no inmunizados contra el virus de la hepatitis B. Se aplicaron tres dosis de 5 µg (0.25 mL) de vacuna intradérmica a las semanas 0, 2 y 4. Se tomó una muestra sérica de 5 mL al ingreso, 2 y 8 semanas después de iniciado el esquema. Los anticuerpos contra el antígeno de superficie del virus de la hepatitis B (antiHB) se cuantificaron por el método de ELISA.
Resultados: se estudiaron 51 individuos negativos para antiHB, 61 % de sexo femenino, edad promedio de 33.5 años. Después de la primera dosis 29 % mostró seroprotección (mediana de 312 mUI/mL), al final del esquema 93 % tuvo antiHB y 78 % alcanzó niveles › 10 mUI/mL.
Conclusiones: con el esquema acelerado de vacunación se alcanza seroconversión en 90 % de los individuos inmunizados. Este esquema induce una inmunidad rápida por lo que podría ser útil en posexposición.


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