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2008, Número 3

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Rev Educ Bioquimica 2008; 27 (3)


El fantástico mundo de la proteína Bcl-2

Luna-López A, López- Diazguerrero NE, González-Puertos VY, Triana-Martínez F, Königsberg FM

Idioma: Español
Referencias bibliográficas: 25
Paginas: 93-102
Archivo PDF: 221.35 Kb.


RESUMEN

Bcl-2 es una proteína que tradicionalmente se ha relacionado con la prevención de la muerte celular programada o apoptosis. Sin embargo, en los últimos años se le han adjudicado otras funciones fisiológicas como son la protección contra el estrés oxidativo, el mantenimiento de la homeostasis del calcio y la regulación del ciclo celular. Todo ello le convierte en una molécula de supervivencia celular. En este artículo se discutirán algunas de esas funciones, se describirá el promotor de Bcl-2 y se mencionarán algunos de los mecanismos que regulan su expresión.


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