medigraphic.com

2010, Número 4

<< Anterior Siguiente >>

Rev Med Inst Mex Seguro Soc 2010; 48 (4)


CXCL5 en el tracto respiratorio superior de niños con influenza A

Duemmler A, Montes-Vizuet AR, Cruz JS, Terán LM

Idioma: Ingles.
Referencias bibliográficas: 27
Paginas: 393-398
Archivo PDF: 45.50 Kb.


RESUMEN

Introducción: la infiltración por neutrófilos es una característica importante en la patogenia de la infección por influenza. Los factores que regulan la afluencia de neutrófilos no están completamente establecidos. Nuestro objetivo fue estudiar la liberación de CXCL5 , potente quimioatrayente de neutrófilos, en niños con influenza naturalmente adquirida.
Métodos: la concentración de CXCL5 fue investigada mediante ensayo inmunoenzimático en aspirados nasales de niños (n = 18) con síntomas respiratorios desencadenados predominantemente por el virus de la influenza A.
Resultados: se encontró incremento en los niveles de CXCL5 en aspirados nasales obtenidos cuando los niños presentaban síntomas respiratorios, comparados con muestras de los mismos niños obtenidas después de cuatro semanas sin síntomas (medianas 1850 pg/mL adversus 30 pg/mL, p ‹ 0.005). CXCL5 fue purificada de las muestras y se demostró actividad biológica quimiotáctica para neutrófilos.
Conclusiones: se sugiere un papel importante para CXCL5 en la atracción de neutrófilos a las vías aéreas superiores en infección respiratoria desencadenada por virus de la influenza, y podría ser un blanco para la intervención terapéutica.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of worldwide distribution of child deaths from acute respiratory infections. Lancet Infect Dis 2002;2(1):25-32.

  2. Morens D. Influenza-related mortality: considerations for practice and public health. JAMA 2003;289(2):227-229

  3. Wold Health Organization. Pandemic (H1N1) 2009-update 74[Internet];2009. Available at http://www.who.int/csr/don/2009_11_27a/en/index.html

  4. Douglas RG Jr, Alford RH, Cate TR, Couch RB. The leukocyte response during viral respiratory illness in man. Ann Intern Med 1966;64(3):521-530.

  5. Wang SZ, Forsyth KD. The interaction of neutrophils with respiratory epithelial cells in viral infection. Respirology 2000;5(1):1-10.

  6. Tate MD, Brooks AG, Reading PC. The role of neutrophils in the upper and lower respiratory tract during influenza virus infection in mice. Respir Res 2008;9:57. Available at http://www.ncbi.nlm.nih. gov/pmc/articles/PMC252 6083/pdf/1465- 9921-9-57.pdf

  7. Yamamoto K, Suzuki K, Suzuki K, Mizuno S. Phagocytosis and ingestion of influenza virus by human polymorphonuclear leukocytes in vitro: electronmicroscopy studies. J Med Microbiol 1989;28(3):191-198. Available at http:// jmm.sgmjournals.org/cgi/reprint/28/3/191

  8. Perrone LA, Plowden JK, García-Sastre A, Katz JM, Tumpey T. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog 2008; 4(8):e1000115. Available at http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2483250/pdf/ppat.1000115.pdf

  9. Tumpey TM, García-Sastre A, Taubenberger JK, Palese P, Swayne DE, Pantin- Jackwood MJ, et al. Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus repli-cation and mortality in mice. J Virol 2005;79(23):14933-14944.

  10. Fujisawa H. Inhibitory role of neutrophils on influenza virus multiplication in the lung of mice. Microbiol Immunol 2001;45(10):679-688.

  11. Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol 2008;82(6):2772-2783. Available at http://www.ncbi.nlm. nih.gov/pmc/articles/PMC2258992/pdf/1210-07.pdf

  12. Ratcliffe D, Nolin SL, Cramer EB. Neutrophil interaction with influenza-infected epithelial cells. Blood. 1988;72(1):142-149. Available at http://bloodjournal. hematologylibrary.org/cgi/reprint/72/1/142

  13. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000;1282):121-127

  14. Walz A, Burgener R, Car B, Baggiolini M, Kunkel SL, Strieter RM. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin-8. J Exp Med. 1991;174(6):1355-1362. Available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119025/pdf/je17461355. pdf

  15. Walz A, Schmutz P, Mueller C, Schnyder-Candrian S. Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. J Leukoc Biol 1997;62(5):604-611. Available at http://www.jleukbio.org/cgi/ reprint/62/5/604

  16. Pauksens K, Fjaertoft G, Douhan-Hakansson L, Venge P. Neutrophil and monocyte receptor expression in uncomplicated and complicated influenza A infection with pneumonia. Scand J Infect Dis 2008;40(4):326-337

  17. Pizzichini MM, Pizzichini E, Efthimiadis A, Chauhan AJ, Johnston SL, Hussack P, et al. Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study. Am J. Respir Crit Care Med 1998;158(4):1178-1184. Available at http://ajrccm.atsjournals.org/cgi/content/full/158/4/1178

  18. Teran, LM, Johnston SL, Schröder J, Church MK, Holgate ST. Role of nasal interleukin8 in neutrophil recruitment and activation in children with virus induced asthma. Am J Respir Crit Care Med 1997;155(4):1362-1366.

  19. Wuytz A, Proost P, Lenaerts JP, Ben-Baruch A, Van Damme J, Wang JM. Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell derived neutrophil attractant-78. Eur J Biochem 1998;255(1):67-73. Available at http://onlinelibrary.wiley.com/doi/10.1046/j.1432- 1327.1998.2550067.x/pdf

  20. Wareing MD, Shea AL, Inglis CA, Dias PB, Sarawar SR. CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance. Viral Immunol 2007;20(3):369-378.

  21. Gern JE, Martin MS, Anklam KA, Shen K, Roberg KA, Carlson-Dakes KT, et al. Relationship among specific viral pathogens, virus induced interleukin- 8, and respiratory symptoms in infancy. Pediatr Allergy Immunol 2002;13(6):386-393.

  22. Hayden FG, Fritz RS, Lobo M, Alvord G, Strober W, Straus SE. Local and systemic cytokine responses during experimental human Influenza A virus infection. J Clin Invest 1998;101(3):643-649.

  23. Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis 2002;2(1):25-32.

  24. Ghildyal R, Dagher H, Donninger H, de Silva D, Li X, Freezer NJ, et al Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and permeability factor. J Med Virol. 2005;75(4):608-615.

  25. Santiago J, Hernández-Cruz JL, Manjarrez-Zavala ME, Montes-Vizuet R, Rosete-Olvera DP, Tapia- Díaz AM, et al. Role of monocyte chemotactic protein- 3 and -4 in children with virus exacerbation of asthma. Eur Respir J 2008;32 (5):1243-1249. Available at http://erj. ersjournals.com/content/32/ 5/1243.full.pdf+html

  26. Donninger H, Glashoff R, Haitchi HM, Syce J, Ghildyal R, van Rensburg E, et al. Rhinovirus induction of the CXC chemokine epithelial activating peptide-78 in bronchial epithelium. J Infect Dis 2003;187(11):1809-1817.

  27. Tecle T, White MR, Gantz D, Crouch EC, Hartshorn KL. Human neutrophil defensins increase neutrophl uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses. J Immunol 2007;178(12):8046-8052. Available at http://www.jimmunol.org/cgi/content/full/178/12/ 8046




2020     |     www.medigraphic.com