Saldaña VR, Hernández PJ, Ramírez RA, González AJ, Meza CME

Idioma: Español
Referencias bibliográficas: 30
Paginas: 194-200
Archivo PDF: 148.39 Kb.

RESUMEN

Objetivo: El presente estudio pretende evaluar la asociación entre la mortalidad a 28 días, escalas de falla multiorgánica, variables hemodinámicas y depuración de lactato a 6 h en pacientes con sepsis severa y choque séptico.
Materiales y métodos: Se realizó un estudio de cohortes de 34 pacientes con sepsis severa y choque séptico en la Unidad de Terapia Intensiva del Hospital Christus Muguerza. Se registró lactato, APACHE II, SOFA, signos vitales, balance acumulado, requerimientos de vasoactivos, esteroides y depuración de lactato a las 6, 24 y 48 h.
Resultados: Se observó una depuración media de lactato a 6 h de -1.18 ± 72.78%. La mortalidad global a 28 días de 44.10%. Para la cohorte de depuración de lactato a 6 h ‹ 10% se estimó un RR de 2.21 con IC 95% [1.02-4.74]. La mortalidad en el grupo de depuración ≥ 10% fue de 26.3% contra 66.7% en el grupo de depuración ‹ 10% (p = 0.01). Se encontró que la depuración de lactato a 6 h de 13.42% tiene el mejor valor de sensibilidad (69.23%) y especificidad (68.42%).
Conclusiones: La depuración de lactato a 6 h es un factor predictor de mortalidad a 28 días en pacientes con sepsis severa y choque séptico.

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