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ISSN 0016-3813 (Impreso)

2012, Número 4

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Gac Med Mex 2012; 148 (4)


Células de la inmunidad innata y adaptativa en la diabetes mellitus tipo 2 y obesidad

Guzmán-Flores JM, López-Briones S

Idioma: Español
Referencias bibliográficas: 74
Paginas: 381-389
Archivo PDF: 113.86 Kb.


RESUMEN

La diabetes mellitus tipo 2 (DM2) y la obesidad son un gran problema de salud pública en México y en todo el mundo por su alta incidencia. La DM2 es consecuencia del defecto de la secreción de insulina, acción de insulina o ambas. También, se ha establecido que tanto la DM2 como la obesidad cursan con un estado inflamatorio crónico de bajo grado, como consecuencia del incremento en la masa del tejido adiposo y la producción de citocinas proinflamatorias. En este proceso participan distintas células del sistema inmune. Las más estudiadas han sido los macrófagos y monocitos, pero recientemente se ha reportado la participación de otras células, tales como neutrófilos, mastocitos, eosinófilos, células dendríticas, natural killer (NK), natural killer de estirpe T (NKT) e inclusive células del sistema inmune adaptativo como los linfocitos Th1, Th2, T reguladoras (Tregs), Th17 y células B. En esta revisión abordamos las recientes evidencias de la participación de las células del sistema inmune, tanto innato como adaptativo, en la patología de la DM2 y la obesidad, concluyendo con la propuesta general de un modelo de la participación de estas células en la inflamación del tejido adiposo, resistencia a la insulina y DM2.


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