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ISSN 0185-3252 (Impreso)
Revista de la Asociación Médica del Centro Médico ABC

1999, Número 3

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An Med Asoc Med Hosp ABC 1999; 44 (3)


Linfadenopatía angioinmunoblástica. Fisiopatología, citogenética, histología y tratamiento

Frenk P, Ylgovsky L

Idioma: Español
Referencias bibliográficas: 33
Paginas: 132-137
Archivo PDF: 144.51 Kb.


RESUMEN

La linfadenopatía angioinmunoblástica, a pesar de ser clínicamente similar a la enfermedad de Hodgkin, es una entidad hiperinmune distinta, aparentemente de linfocitos B. Es una enfermedad caracterizada por síntomas constitucionales y linfadenopatía. El diagnóstico se establece mediante biopsia del ganglio linfático, con la cual se observan alteraciones en la morfología del mismo, ausencia de centros germinativos, arborización de vénulas poscapilares y un infiltrado polimorfo que incluye inmunoblastos. Los hallazgos de laboratorio incluyen, anemia hemolítica autoinmune e hipergammaglobulinemia policlonal.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Lukes JR, Tindle HB. Immunoblastic lymphadenopathy: A hyperimmune entity resembling Hodgkin’s disease. N Engl J Med 1975; 292: 1-8.

  2. Murayama T, Imoto Sh, Takahashi T, Mitsuhiro I, Matozaki S, Nakagawa T. Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with ciclosporin A. Cancer 1992; 69: 2567-2570.

  3. Siegert W et al. Treatment of angioimmunoblastic lymphadenopathy (aild)-type t-cell lymphoma using prednisone with or without the COPBLAM/IMV-16 regimen. A multicenter study. Ann Intern Med 1992; 117: 364-370.

  4. Esténs RM, Hernández BF, Gabayet KD, Saita KO. Linfadenopatía angioinmunoblástica. Presentación de un caso clínico. Med Inter Mex 1989; 5: 28-32.

  5. Knecht H. Angioimmunoblastic lymphadenopathy: Ten year’s experience and state of current knowledge. Semin Hematol 1989; 26: 208-215.

  6. Fest T, Angonin R, Dupond JL, Caln JY. Angioimmunoblastic lymphadenopathy: A pathogenic intersection between dysimmune, viral and lymphomatous disease. Rev Med Interne 1991; 12: 383-388.

  7. Li GD, Lorenzen J, Hansmann MI. Detection of T-cell receptor gamma V gene rearrangements in angioimmunoblastic lymphadenopathy type T-cell lymphoma by PCR and family specific primers. Chung-hua-Ping-Li-Hsueh-Tsa-Chin 1994; 23: 211-224.

  8. Honda M, Smith RH, Steinberg DA. Studies of the pathogenesis of angioimmunoblastic lymphadenopathy. J Clin Invest 1985; 76: 332-340.

  9. Steinberg et al. Angioimmunoblastic lymphadenopathy with dysproteinemia. NIH Conference. Ann Intern Med 1988; 108: 575-584.

  10. Yu AM, Song RL, Yu Z, Chen YP, Wang FZ et al. Detection of human cytomegalovirus antigen and DNA in lymph nodes and peripheral blood mononuclear cells of patients with angioimmunoblastic lymphadenopathy with dysproteinemia. Arch Pathol Lab Med 1992; 116: 490-494.

  11. Medeiros LJ et al. Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood 1992; 79: 1789-1795.

  12. Oshima K, Takeo H, Kikuchi M, Uike N et al. Heterogeneity of Epstein-Barr virus infection in angioimmunoblastic lymphadenopathy type T-cell lymphoma. Histopathology 1994; 25: 569-579.

  13. Knecht H, Martius F, Bachman ET et al. A deletion mutant of the LMP1 oncogene of Epstein-Barr virus is associated with evolution of angioimmunoblastic lymphadenopathy into B immunoblastic lymphoma. Leukemia 1995; 9: 458-465.

  14. Kanzaki Y, Eura M, Chikamatsu K, Yoshida M, Musuyama K et al. Angioimmunoblastic lymphadenopathy like T-cell lymphoma. A case report and immunologic study. Auris Nasus Larynx 1997; 24 (2): 199-206.

  15. Takagi N et al. A phenotypic and genotypic study of three node-based, low grade peripheral T-cell lymphomas: angioimmunoblastic lymphoma, T zone lymphoma, and lymphoepithelioid lymphoma. Cancer 1992; 69: 2571-2582.

  16. Cosimi MF, Casagranda I, Ghiazza G, Rossi G, Galvani P. Rearrangements on chromosomes 7 and 14 with breakpoints at 7q35 and 14q11 in angioimmunoblastic lymphadenopathy and IBL-like T cell-lymphoma. Pathologica 1990; 82: 391-397.

  17. Lorenzen J, Li G, Zhao HM, Wintzeer C, Fischer R, Hansmann ML. Angioimmunoblastic lymphadenopathy type of T-cell lymphoma and angioimmunoblastic lymphadenopathy: A clinicopathological and molecular biological study of 13 Chinese patients using polymerase chain reaction and paraffin-embedded tissues. Virchows-Arch 1994; 424: 593-600.

  18. Schlegelberger B, Zwingers T, Hohennadel K, Hemmebruns D, Schmitz N et al. Significance of cytogenetic findings for the clinical outcome in patients with T cell lymphoma of angioimmunoblastic lymphadenopathy type. J Clin Oncol 1996; 14 (2): 593-9.

  19. Schlegelberger B, Zhang Y, Weber MK, Grote W. Detection of aberrant clones in nearly all cases of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combines interface and metaphase cytogenetics. Blood 1994; 84: 2640-2648.

  20. Bagilet D, Diab M, Aristiqui R, Magaro J, Sivori O, Naves A. Angioimmunoblstic lymphadenopathy and colonic lymphoma. Medicina 1990; 50: 548-552.

  21. Goenka MK, Vaiphei K, Nagi B, Sriram PV, Joshi K, Kochhar R. Angioimmunoblastic lymphadenopathy: An etiology for gastrointestinal lymphomatous polyposis. AM J Gastroenterol 1996; 91 (6): 1236-8.

  22. Cavanna I, Di Stasi M, Paties C, Formari F, Civardi G et al. Angioimmunoblastic lymphadenopathy with dysproteinemia associated with carcinoma. Case report and review of the literature. Oncology 1988; 45: 318-321.

  23. Chang HJ, Su IJ, Chen CL, Chiang IP, Chen YC et al. Angioimmunoblastic Lymphadenopathy with dysproteinemia, lack of a prognostic value of clear cell morphology. Oncology 1997; 54 (3): 193-198.

  24. Foss HD, Anagostopoulus I, Herbst H, Grebe M, Ziemann K et al. Patterns of cytokine gene expression in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. Blood 1995; 85: 2862-2869.

  25. Schmiez NM, Pange E, Harariach T, Griesse H, Sonnen R, Schlegelberger B. High dose chemotherapy and autologous bone marrow transplantation in relapsing angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Bone Marrow Transplant 1991; 8: 503-506.

  26. Schauer P et al. Angioimmunoblastic lymphadenopathy: clinical spectrum of disease. Cancer 1981; 48: 2493-2498.

  27. Saramotos et al. Clinicopathologic and therapeutic aspects of angioimmunoblastic lymphadenopathy-related lesions. Cancer 1992; 69: 1259-1267.

  28. Upara S, Ruchutrakool T, Sukpanichnant S. Lymph node pathology in patients with a clinical diagnosis of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD): An analysis of 37 cases. Asian-Oac-J-Allergy-Immunol 1997; 15 (1): 15-20.

  29. Schmut M, Ramaker J, Trautman C, Hummel M, Schmitt GA, Stein H, Goerdt S. Cutaneous involvement in prelymphomatous angioimmunoblastic lymphadenopathy. J AM Acad Dermatol 1997; 36 (2): 290-295.

  30. Sallah AS, Bernard S. Treatment of angioimmunoblastic lymphadenopathy with dysproteinemia using 2-chlorodeoxyadenosine. Ann Hematol 1996; 73 (6): 295-296.

  31. Abruzzo LV, Weiss LM. B cell-lymphoma arising in angioimmunoblastic lymphadenopathy: A case of oligoclonal gene rearrangements associated with Epstein-Barr virus. Blood 1993; 82: 241-246.

  32. Siegert W, Nerl C, Meuthen I, Zahn T, Brack N et al. Recombinant Human Interferon-Alfa in the Treatment of Angioimmunoblastic Lympadenopathy: results in 12 Patients. Leukemia 1991; 5: 892-895.

  33. Ong ST, Koeppen H, Larson RA, Olopade OI. Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with fludarabine. Blood 1996; 88 (6): 2354-2355.




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