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2011, Número 3

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Rev Mex Med Repro 2011; 3.4 (3)


Fragmentación del ADN del espermatozoide y su influencia en la fertilidad de la pareja

Góngora RA, Sánchez GS, Cubillos GS, Cuneo PS

Idioma: Español
Referencias bibliográficas: 65
Paginas: 105-111
Archivo PDF: 99.28 Kb.


RESUMEN

La fragmentación del ADN del espermatozoide es actualmente una herramienta complementaria importante en reproducción asistida porque con ella se evalúa la calidad del semen de un paciente. Sin embargo, ningún parámetro seminal por sí mismo puede considerarse valor diagnóstico absoluto de infertilidad masculina. El índice de fragmentación del ADN permite inferir datos sobre la capacidad de fertilización del espermatozoide. Diversos estudios han demostrado que en hombres infértiles es mayor el índice de fragmentación de la cromatina de sus espermatozoides, y esto se ha correlacionado directamente con disminución de la calidad embrionaria, la tasa de implantación y el desarrollo a término de un embarazo sano.


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