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2012, Número 1

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Biotecnol Apl 2012; 29 (1)


Un acercamiento actualizado a la Esclerosis Múltiple

Pedroso-Santana S

Idioma: Ingles.
Referencias bibliográficas: 92
Paginas: 1-6
Archivo PDF: 152.20 Kb.


RESUMEN

La Esclerosis Múltiple (EM) es una enfermedad inflamatoria desmielinizante crónica del Sistema Nervioso Central, y de patogenia desconocida, para la que actualmente no existe cura. Las causas que la desencadenan parecen estar relacionadas a componentes genéticos y ambientales y la teoría más aceptada enuncia que la enfermedad ocurre ante una ruptura del balance inmunorregulatorio ‘células T activas/células T reguladoras’; mientras que algunas evidencias muestran también la incidencia del estrés oxidativo en la enfermedad. Las terapias que pueden reducir o detener los síntomas clínicos y la aparición de las lesiones no pueden detener la progresión de la EM, es por esto que numerosos esfuerzos continúan realizándose para encontrar un tratamiento nuevo y eficiente. La unificación de la información procedente de la clínica con la derivada de los análisis moleculares pudiera brindar mayor precisión en la búsqueda de un tratamiento específico. En la medida en que se mejore el conocimiento sobre los mecanismos de acción de estas drogas se podrán aplicar mejores combinaciones de drogas y mejores terapias.


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