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Colegio de Medicina Interna de México.

2012, Número 3

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Med Int Mex 2012; 28 (3)


Vitamina D en el enfermo grave. Conceptos actuales

Carrillo ER, Zárate VV

Idioma: Español
Referencias bibliográficas: 55
Paginas: 262-268
Archivo PDF: 485.81 Kb.


RESUMEN

La vitamina D es una vitamina liposoluble que tiene efectos pleiotrópicos en la inmunidad, en la función endotelial y de las mucosas y en el metabolismo de la glucosa y del calcio. La demanda tisular de la vitamina D se incrementa durante la infección, las alteraciones metabólicas y la inflamación. La deficiencia de vitamina D se toma poco en cuenta y no es tratada en pacientes críticamente enfermos. Estudios recientes en la unidad de terapia intensiva revelan una alta prevalencia de hipovitaminosis D que se asocia con incrementos de la morbilidad y de la mortalidad. La causa de la hipovitaminosis D en el paciente crítico es secundaria a limitada exposición a la luz solar, a disfunción en el metabolismo de la vitamina D y de la función paratiroidea. La suplementación de vitamina D es necesaria en el paciente grave y, de acuerdo con estudios recientes, con dosis elevadas para lograr mantener concentraciones séricas. El objetivo de este trabajo es revisar los conceptos relacionados con el papel de la vitamina D en los enfermos graves.


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