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Colegio de Medicos y Cirujanos República de Costa Rica

2008, Número 584

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Rev Med Cos Cen 2008; 65 (584)


Uso de celulas madre en la terapeutica de las enfermedades cardiovasculares: desde la ciencia basica a la aplicación clinica
Parte III: Aplicación Clínica

Zeledón SF, Escalante GC, Morales MO, Méndez JE

Idioma: Español
Referencias bibliográficas: 53
Paginas: 222-228
Archivo PDF: 356.00 Kb.


FRAGMENTO

Introducción

¿Cuál Célula Madre Transplantar? Varios tipos celulares han sido considerados para un potencial tratamiento de las enfermedades cardiacas, dentro de las cuales destacan la cardiopatía isquémica, las miocardiopatías y la insuficiencia cardiaca de cualquier etiología. A continuación se resumiran las ventajas y desventajas de cada tipo célula, excluyendo las CMDTA, las cuales no han sido bien estudiadas en el momento de la redacción de este artículo.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Angelini P, Markwald R. Stem Cell Treatment of the Heart. Tex Heart Inst J 2005; 32:479-88.

  2. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997 275:964-7.

  3. Ashman LK. The biology of stem cell factor and its receptor c-kit. The International Journal of Biochemistry and Cell Biology. 1999; 31:1037-1051.

  4. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematpoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004;428:668-73.

  5. Behfar A, Zingman LV, Hodgson DM. Stem cell differentiation requires a paracrine pathway in the heart. FASEB J 2002;16:1558-66.

  6. Beltrami AP, Barlucchi L, Torella D, et col. Adult cardiac stem cell are multipotent and support myocardial regeneration. Cell 2003:114:763-76.

  7. Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescoci AL. Turning brain into blood: a hematopoietic fate adopted by neural stem cells in vivo. Science 1999;283:534-7.

  8. Blackburn EH. Structure and function of telomeres. Nature. 1991;350:569-573,

  9. Caparelli DJ, Cattaneo S, Shake JG, et col. Cellular cardiomyoplasty with allogenic mesenchymal stem cells results in improved cardiac performance in a swine model of myocardial infarction. Circulation 2001;104(suppl II): II-599.

  10. Chiu RCJ. “Stealth lmmune Tolerance” in Stem Cell Transplantation: Potential for “Universal Donors” in Myocardial Regenerative Therapy. J Heart Lung Transplant 2005;24:511-516.

  11. Dimmeler S. Viewpoint: Stem Cells in Cardiology. Circulation 2006;113:69-72.

  12. Eisenberg LM, Eisenberg CA. Adult Stem Cell and Their Cardiac Potential. Anat Rec Part A 2004; 276:103-112.

  13. Ferrari G. Cusella-De Angelis G, Coletta M, et col. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279: 1528-30.

  14. Forrester JS, Price MJ, Makkar RR. Stem cell repair of Infarcted Myocardium: an overview for clinicians. Circulation 2003;108:1139-1145.

  15. Fraser JK, Schreiber RE, Zuk PA, Hedrick MH. Adult stem cell therapy for the heart. The International Journal of Biochemistry and Cell Biology 2004;36:658-666.

  16. Friedrich EB, Bohm M. Human umbilical cord blood cells and myocardial infarction: Novel ways to treat an old problem. Circ Res 2005;66:4-6.

  17. Haider KH, Jiang SJ, Ye L. Transient immunosuppression is effective for xenotransplantation of human myoblasts for cardiac repair in a porcine heart mode. Circulation 2002;16:106-69.

  18. Heeschen C, Aicher A, Lehmann R, et col. Erythropoietin is a potent physiologic stimulus for endothelial progenitor Cell mobilitation. Blood 2003;102:1340-1346.

  19. Hiyama K, Hirai Y, Kyoizumi S, et col. Activation of telomerase in human lymphocytes and hemaopoietic progenitor cells. J lmmunol. 1995; 155:3711-3715.

  20. Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA 1999;96:1482-6.

  21. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005; 19:1129-1255.

  22. Krause DS, Theise ND, Collector MI, et col. Multi-organ, multilineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-77.

  23. 23.Lagasse E, Connors H, Al-Dhalimy M, et col. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-34.

  24. Lapidot T, Petit I. Current understanding of stem celI mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol. 2002; 30:973-981.

  25. Laugwitz KL. Moretti A, Lam J, et col. Postnatal isl-1+ cardioblasts enter fully differentiated cardiomyocite lineages. Nature 2005;433:647-53.

  26. Leri A, Kajstura J, Anversa E Cardiac Stem Cells and Mechanisms of Myocardial Regeneration. Physiol Rev. 2005;85:1373-1416.

  27. Levine M, Hoey T. Homeobox proteins as sequence-specific transcription factors. CeIl. 1998; 55:537-540.

  28. Liechty KW, Mackenzie TC, Shaaban A, et col. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Med 2000; 6:1282-6.

  29. Linnekin D. Early signaling pathways activated by c-kit in hematopoietic cells. The International Journal of Biochemistry and Cell Biology. 1999; 31:1053-1074.

  30. Makkar RR, Price M, LilI M. Multilineage differentiation of transplanted allogenic mesenchymal stem cells in a porcine model of recent myocardial infarction improves left ventricular function. Circulation 2002;106(suppl II):II34.

  31. Matzinger P. An innate sense of danger. Sem lmmunol 1998;10:399-415.

  32. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296:301-5.

  33. Méndez-Ferrer S, Ellison GM, Torella D, Nadal-Ginard B. Resident progenitors and bone marrow stem cells in myocardial renewal and repair. Nature Clinical Practice Cardiovascular Medicine. 2006;3:s83-s89.

  34. Mezey E, Chandross KJ, Harta G, Maki RA, Mckercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000;290: 1779-82.

  35. Min JY, Yang Y, Converso KL, et col. Transplantation of embryonic stem cells improves cardiac function in postinfarted rats. J Appl Physiol 2002;92:288-96.

  36. Murry ChE, Reinecke H, Pahon LM. Regeneration Gaps: observations on stem cells and cardiac repair. J Am ColI Cardiol 2006;47: 1777-85.

  37. Nygren JM, Jovinge S, Breitbach M, et col. Bone marrow-derived hematopoietic cells generate cardyomicytes at a low frequency through cell fusion, but no transdifferentation Nat Med 2004;10:494-501.

  38. Orlic D, Kajstura J, Chimenti S, et col. Bone Marrow cells regenerate infarcted myocardium. Nature 2001;410:701-5.

  39. Perin EC, López J. Methods of stem cell delivery in cardiac diseases. Nature Clinical Practice Cardiovascular Medicine 2006; 3: s110-s113.

  40. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004; 95:9-20.

  41. Reya T, Duncan AW, Ailles L, et col. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature. 2003; 423:409-414.

  42. Saha M, Ferro A. Cardiac stem cell therapy: present and future. Br J Clin Pharmacol 2006; 61:727-729.

  43. Schober A, Karshovska E, et col. SDF-1 alfa Mediated Tissue Repair by Stem Cells: A Promising Tool in Cardiovascular Medicine?. 2006; 16: 103-108.

  44. Saito T, Kuang JQ, Bittira B, Al-khaldi A, Chiu RCJ. Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 2002;74:19-24.

  45. Siepe M, Heilmann C, von Samson P, et col. Stem cell research and cell transplantation for myocardial regeneration. Eur J Cardiothorac Surg 2005; 28:318-324.

  46. Stein MI, Zhu J, Emerson SG. Molecular pathways regulating the selfrenewal of haematopoietic stem cell. Exp Hematol. 2004; 32:1129- 1136.

  47. Torella D, Ellison GM, et col. Resident human cardiac stem ceIls : role in cardiac cellular homeostasis and potential for myocardial regeneration. Nature Clinical Practice Cardiovascular Medicine. 2006;3:s8-s13.

  48. Vandervelde S, van Luyn MJA, Tio RA, Harmsen MC. Signaling factors in stem cellmediated repair of infarted myocardium. J Mol Cell Cardiol. 2005; 39:363-376.

  49. Wald MR, Borda ES, Sterin —Borda L. Mitogenic effect of erithropoietin on neonatal rat cardiomyocites: signal transduction pathways. J Cell Physiol. 1996; 167:461-468.

  50. Wollert K, Drexler H. CelI-based therapy for heart failure. Curr Opin Cardiol 2006; 21:234-239.

  51. Xiao YF, Min JY, Morgan JP. Immunosuppression and Xenotransplantation of Cells for Cardiac Repair. Ann Thorac Surg 2004;77:73744

  52. Zeledón FS, Morales O, Méndez EJ, et col. Células madre en la reparación de tejido miocárdico: Biología y Clínica. Revista Costarricense de Cardiología. 2005; 7: 13-20.

  53. Zuk PA, Zhu M, Ashjian P et al. Human Adipose Tissue is a Source of Multipotent Stem CelIs. Mol Biol Cell 2002; 13: 4279-4295.




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