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2012, Número 2

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Rev cubana med 2012; 51 (2)


Base genética de la enfermedad celiaca en el diagnóstico

Torres OS, Martínez CZ

Idioma: Español
Referencias bibliográficas: 33
Paginas: 170-182
Archivo PDF: 167.99 Kb.


RESUMEN

La enfermedad celiaca es un síndrome de malabsorción caracterizado por intolerancia a las proteínas del gluten en individuos genéticamente predispuestos con los alelos HLA-DQ2/DQ8. Su causa es multifactorial y los factores dietéticos, ambientales y genéticos tienen una significación importante en su aparición. El diagnóstico temprano posibilita prevenir complicaciones como la osteopenia, las enfermedades malignas y la infertilidad. El objetivo de este estudio fue compilar información actualizada sobre la base genética de esta enfermedad y su papel en el diagnóstico.


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