Guardado-Mendoza R

Idioma: Español
Referencias bibliográficas: 10
Paginas: 167-169
Archivo PDF: 72.51 Kb.

FRAGMENTO

Contexto: La terapia con levotiroxina (L-T4) está basada en el supuesto de que la conversión de T4 a T3 provee cantidades adecuadas de hormona activa en los tejidos blancos. Sin embargo, en roedores la L-T4 sola no restaura un estado eutiroideo en todos los tejidos. Estudios previos de terapia combinada de L-T4/liothyronine (L-T3) se han enfocado en eventos de desenlace relacionados con la calidad de vida; sin embargo, aún existe información limitada de los efectos sobre otras mediciones de acción de la hormona tiroidea.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Clyde PW, Harari AE, Getka EJ, Shakir KM. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: A randomized controlled trial. JAMA 2003; 290: 2952-2958.

2. Escobar-Morreale HF, Botella-Carretero JI, Gómez-Bueno M, Galán JM, Barrios V, Sancho J. Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med 2005; 142: 412-424.

3. Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3’-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003; 88: 4551-4555.

4. Walsh JP, Shiels L, Lim EM, Bhagat CI, Ward LC, Stuckey BG et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J Clin Endocrinol Metab 2003; 88: 4543-4550.

5. Grozinsky-Glasberg S, Fraser A, Nahshoni E, Weizman A, Leibovici L. Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 2006; 91: 2592-2599.

6. Escobar-Morreale HF, del Rey FE, Obregón MJ, de Escobar GM. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology 1996; 137: 2490-2502.

7. Celi FS, Zemskova M, Linderman JD, Babar NI, Skarulis MC, Csako G et al. The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. Clin Endocrinol (Oxf) 2010; 72: 709-715.

8. Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V et al. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab 2011; 96: 3466-3474.

9. Fadeyev VV, Morgunova TB, Melnichenko GA, Dedov II. Combined therapy with L-thyroxine and L-triiodothyronine compared to L-thyroxine alone in the treatment of primary hypothyroidism. Hormones (Athens) 2010; 9: 245-252.

10. Regalbuto C, Maiorana R, Alagona C, Paola RD, Cianci M, Alagona G et al. Effects of either LT4 monotherapy or LT4/LT3 combined therapy in patients totally thyroidectomized for thyroid cancer. Thyroid 2007; 17: 323-331.