2011, Número 4
<< Anterior Siguiente >>
Arch Neurocien 2011; 16 (4)
Neurogénesis en el giro dentado del hipocampo: implicaciones para el aprendizaje y la memoria en el cerebro adulto
Nieto-Escamez FA, Moreno-Montoya M
Idioma: Español
Referencias bibliográficas: 69
Paginas: 193-199
Archivo PDF: 64.94 Kb.
RESUMEN
Durante los últimos años las neurociencias han mostrado un interés creciente, por los mecanismos de neurogénesis en el
cerebro adulto. Una parte de estudios realizados han estado centrados en el posible papel de estas nuevas neuronas sobre
los procesos de memoria y aprendizaje.
Objetivos: revisar los últimos estudios sobre la posible relación entre neurogénesis
en el hipocampo del cerebro adulto y procesos cognitivos como aprendizaje y memoria.
Desarrollo: una de las estructuras
donde nacen nuevas neuronas a lo largo de la vida es el giro dentado del hipocampo. Es sabido que esta estructura está
relacionada con los procesos de memoria y aprendizaje, por lo que se ha sugerido una posible participación de las nuevas
neuronas nacidas en el hipocampo adulto a nivel de procesamiento de información.
Conclusiones: los datos existentes en
la actualidad no proporcionan evidencias claras sobre los procesos cognitivos mediados por las nuevas neuronas generadas
en el cerebro adulto. Así, su implicación parece depender en buena medida de las características de la tarea y protocolo
experimental utilizado; por tanto, los estudios futuros deberán tener en cuenta estos factores a fin de establecer con mayor
certeza la implicación de la neurogénesis en el hipocampo adulto en procesos de memoria y aprendizaje.
REFERENCIAS (EN ESTE ARTÍCULO)
Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 2001; 435: 406-17.
Christie BR, Cameron HA. Neurogenesis in the adult hippocampus. Hippocampus 2006; 16:199-207.
Rao MS, Shetty AK. Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. Eur J Neurosci 2004;19:234-46.
Dayer AG, Ford AA, Cleaver KM, Yassaee M, Cameron HA. Short-term and long-term survival of new neurons in the rat dentate gyrus. J Comp Neurol 2003;460:563-72.
Leuner B, Mendolia-Loffredo S, Kozorovitskiy Y, Samburg D, Gould E, Shors TJ. Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. J Neurosci 2004;24:7477-81.
Ramirez-Amaya V, Marrone DF, Gage FH, Worley PF, Barnes CA. Integration of new neurons into functional neural networks. J Neurosci 2006;26:12237-41.
Laplagne DA, Esposito MS, Piatti VC, Morgenstern NA, Zhao C, van Praag H, et al. Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol 2006;4: e409.
Aimone JB, Deng W, Gage FH. Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci 2010; 14:325-37.
Eichenbaum H. A cortical‘ hippocampal system for declarative memory. Nat Rev. Neurosci 2000;1:41-50.
Dalla C, Bangasser DA, Edgecomb C, Shors TJ. Neurogenesis and learning: acquisition and asymptotic performance predict how many new cells survive in the hippocampus. Neurobiol Learn Mem 2007;88:143-8.
Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997; 386: 493-5.
Montaron MF, Drapeau E, Dupret D, Kitchener P, Aurousseau C, Le Moal M, et al. Lifelong corticosterone level determines agerelated decline in neurogenesis and memory. Neurobiol Aging 2006;27:645-54.
Lemaire V, Koehi M, Le Moal M, Abrous DN. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A 2000; 97:11032-7.
Mohapel P, Leanza G, Kokaia M, Lindvall O. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging 2005;26:939-46.
Madsen TM, Kristjansen PE, Bolwig TG, Wortwein G. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 2003;119:635-42.
Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 1999;2:260-5.
Ambrogini P, Orsini L, Mancini C, Ferri P, Ciaroni S, Cuppini R. Learning may reduce neurogenesis in adult rat dentate gyrus. Neurosci Lett 2004;359:13-6.
MD Dobrossy, E Drapeau, C Aurousseau, Moal M LE, Piazza PV, Abrous DN. Differential effects of learning on neurogenesis: Learning increases or decreases the number of newly born cells depending on their birth date. Mol Psychiatry 2003;8:974-82.
Kempermann G, Gage FH. Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci 2002;16:129-36.
Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, et al. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A 2003;100:6777-82.
Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R, et al. NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem 2006;13:307-15.
Drapeau E, Mayo W, Aurousseau C, Le Moal M, Piazza PV, Abrous DN. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc Natl Acad Sci U S A 2003;100:14385-90.
Van der Borght K, Wallinga AE, Luiten PG, Eggen BJ, Van der Zee EA. Morris water maze learning in two rat strains increases the expression of the polysialylated form of the neural cell adhesion molecule in the dentate gyrus but has no effect on hippocampal neurogenesis. Behav Neurosci 2005;119:926-32.
Ambrogini P, Cuppini R, Cuppini C, Ciaroni S, Cecchini T, Ferri P, et al. Spatial learning affects immature granule cell survival in adult rat dentate gyrus. Neurosci Lett 2000;286:21-4.
Hairston IS, Little MT, Scanlon MD, Barakat MT, Palmer TD, Sapolsky RM, et al. Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning. J Neurophysiol 2005; 94:4224-33.
Olariu A, Cleaver KM, Shore LE, Brewer MD, Cameron HA. A natural form of learning can increase and decrease the survival of new neurons in the dentate gyrus. Hippocampus 2005;15: 750-62.
Leuner B, Waddell J, Gould E, Shors TJ. Temporal discontiguity is neither necessary nor sufficient for learning-induced effects on adult neurogenesis. J Neurosci 2006;26:13437-42.
Sisti HM, Glass AL, Shors TJ. Neurogenesis and the spacing effect: Learning over time enhances memory and the survival of new neurons. Learn Mem 2007;14:368-75.
van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A 1999;96:13427-31.
Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM. A role for adult neurogenesis in spatial long-term memory. Neuroscience 2005; 130:843-52.
Pham K, McEwen BS, Ledoux JE, Nader K. Fear learning transiently impairs hippocampal cell proliferation. Neuroscience 2005;130: 17-24.
Dupret D, Fabre A, Dobrossy MD, Panatier A, Rodriguez JJ, Lamarque S, et al. Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol 2007;5:e214.
Epp JR, Haack AK, Galea LA. Task difficulty in the morris water task influences the survival of new neurons in the dentate gyrus. Hippocampus 2010;20:866-76.
Aimone JB, Deng W, Gage FH. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron 2011;70:589-96.
Saxe MD, Malleret G, Vronskaya S, Mendez I, Garcia AD, Sofroniew MV, et al. Paradoxical influence of hippocampal neurogenesis on working memory. Proc Natl. Acad Sci U S A 2007;104:4642-6.
Clelland CD, Choi M, Romberg C, Clemenson GD,Jr, Fragniere A, Tyers P, et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 2009; 325: 210-3.
Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature 2001; 410: 372-6.
Zhang CL, Zou Y, He W, Gage FH, Evans RM. A role for adult TLXpositive neural stem cells in learning and behaviour. Nature 2008;451:1004-7.
Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 2006;103:17501-6.
Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 2006;16:296-304.
Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E. Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 2002;12:578-84.
Wojtowicz JM, Askew ML, Winocur G. The effects of running and of inhibiting adult neurogenesis on learning and memory in rats. Eur J Neurosci 2008;27:1494-502.
Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 2004;162:39-47.
Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L, et al. Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 2006;9:729-31.
Garthe A, Behr J, Kempermann G. Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS One 2009;4:e5464.
Hernandez-Rabaza V, Llorens-Martin M, Velazquez-Sanchez C, Ferragud A, Arcusa A, Gumus HG, et al. Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. Neuroscience 2009;159:59-68.
Olson AK, Eadie BD, Ernst C, Christie BR. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 2006;16:250-60.
Kee N, Teixeira CM, Wang AH, Frankland PW. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci 2007;10: 355-62.
Tashiro A, Makino H, Gage FH. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci 2007; 27: 3252-9.
Deng W, Aimone JB, Gage FH. New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 2010; 11: 339-50.
van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 2005;25:8680-5.
Bruel-Jungerman E, Laroche S, Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced longterm memory following environmental enrichment. Eur J Neurosci 2005;21:513-21.
Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, et al. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 2001;32:911-26.
Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997;17:2492-8.
Seki T, Arai Y. Age-related production of new granule cells in the adult dentate gyrus. Neuroreport 1995;6:2479-82.
Tanapat P, Hastings NB, Rydel TA, Galea LA, Gould E. Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. J Comp Neurol 2001;437:496-504.
Drapeau E, Montaron MF, Aguerre S, Abrous DN. Learning-induced survival of new neurons depends on the cognitive status of aged rats. J Neurosci 2007;27:6037-44.
Mirescu C, Gould E. Stress and adult neurogenesis. Hippocampus 2006;16:233-8.
Zhang WJ, Tan YF, Yue JT, Vranic M, Wojtowicz JM. Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand 2008;117:205-10.
Bizon JL, Gallagher M. Production of new cells in the rat dentate gyrus over the lifespan: Relation to cognitive decline. Eur J Neurosci 2003;18:215-9.
Akirav I, Kozenicky M, Tal D, Sandi C, Venero C, Richter-Levin G. A facilitative role for corticosterone in the acquisition of a spatial task under moderate stress. Learn Mem 2004; 11: 188-95.
Bartolomucci A, de Biurrun G, Czeh B, van Kampen M, Fuchs E. Selective enhancement of spatial learning under chronic psychosocial stress. EurJ Neurosci 2002;15:18.63-6.
Wood GE, Beylin AV, Shors TJ. The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning in males versus females. Behav Neurosci 2001; 115:175-87.
Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ. Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci U S A 2000;97:7579-84.
Abrous DN, Adriani W, Montaron MF, Aurousseau C, Rougon G, Le Moal M, et al. Nicotine self-administration impairs hippocampal plasticity. J Neurosci 2002;22:3656-62.
Nixon K, Crews FT. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem 2002; 83: 1087-93.
Spain JW, Newsom GC. Chronic opioids impair acquisition of both radial maze and Y-maze choice escape. Psychopharmacology [Berl] 1991;105:101-6.
Matthews DB, Silvers JR. The use of acute ethanol administration as a tool to investigate multiple memory systems. Neurobiol Learn Mem 2004;82:299-308.
Scerri C, Stewart CA, Breen KC, Balfour DJ. The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation into the dentate gyrus of the rat. Psychopharmacology [Berl] 2006;184:540-6.