2009, Número 587
<< Anterior Siguiente >>
Rev Med Cos Cen 2009; 66 (587)
Obesidad y cáncer: Un enfoque epidemiológico
Soto MT, Lagos SE
Idioma: Español
Referencias bibliográficas: 30
Paginas: 27-32
Archivo PDF: 293.31 Kb.
RESUMEN
La agencia internacional para la investigación en cáncer ha determinado que basado en los resultados de estudios epidemiológicos las personas que tienen sobrepeso u obesidad están en un mayor riesgo de desarrollar varios tipos de cáncer que incluye al adenocarcinoma de esófago, cáncer de colon, cáncer de mama (en mujeres postmenpausicas), cáncer de endometrio y cáncer de riñón (de células claras). La evidencia epidemiológica también indica que los tumores malignos de hígado, vesícula biliar, y páncreas, están relacionados con la obesidad. Además estos estudios han establecido, que la obesidad puede aumentar el riesgo de malignidad hematopoyetica y para cáncer de próstata agresivo. No existe ninguna asociación entre la obesidad y el cáncer de pulmón. Los resultados para otros canceres han sido inconsistentes.
REFERENCIAS (EN ESTE ARTÍCULO)
Amling CL, Riffenburgh RH, Sun L et al. Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol 2004; 22(3):439-445.
Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4(8):579-591.
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348(17):1625-1638.
Chow WH, Blot WJ, Vaughan TL et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 1998; 90(2):150-155.
Dickson RB, Stancel GM. Estrogen receptor-mediated processes in normal and cancer cells. J Natl Cancer Inst Monogr 2000;(27):135-145.
Feigelson HS, Jonas CR, Teras LR, Thun MJ, Calle EE. Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev 2004; 13(2):220-224.
Folsom AR, Kaye SA, Prineas RJ, Potter JD, Gapstur SM, Wallace RB. Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women. Am J Epidemiol 1990; 131(5):794-803.
Giovannucci E. Insulin and colon cancer. Cancer Causes Control 1995; 6(2):164-179.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 1995; 122(5):327-334.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Height, body weight, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 1997; 6(8):557-563.
Grundy SM, Cleeman JI, Merz CN et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110(2):227-239.
Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 2001; 60(1):91-106.
Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev 2002; 11(12):1531-1543.
Keown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev 1994; 3(8):687-695.
Key TJ, Allen NE, Verkasalo PK, Banks E. Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 2001; 60(1):81-89.
Key TJ, Appleby PN, Reeves GK et al. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003; 95(16):1218-1226.
Key TJ, Pike MC. The dose-effect relationship between ‘unopposed’ oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer 1988; 57(2):205-212.
Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 2000; 21(3):215-244.
Lagergren J, Bergstrom R, Adami HO, Nyren O. Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma. Ann Intern Med 2000; 133(3):165-175.
Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001; 114(Pt 16):2903-2910.
Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis 1979; 32(8):563-576.
Lindblad P, Chow WH, Chan J et al. The role of diabetes mellitus in the aetiology of renal cell cancer. Diabetologia 1999; 42(1):107-112.
Petrelli JM, Calle EE, Rodriguez C, Thun MJ. Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control 2002; 13(4):325-332.
Rajala MW, Scherer PE. Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144(9):3765-3773.
Tchernof A, Despres JP. Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women. Horm Metab Res 2000; 32(11-12):526-536.
Vainio H, Kaaks R, Bianchini F. Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 2002; 11 Suppl 2:S94-100.
Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21(6):697-738.
Wardle J, Jarvis M, et.al. Socioeconomic disparities in cancer-risk behaviours in adolescence baseline results from the health and behviour in teenager study (HABITS). Prev Med 2003; 36:721-730.
Wee CC, McCarthy EP, Davis RB, Phillips RS. Screening for cervical and breast cancer: is obesity an unrecognized barrier to preventive care? Ann Intern Med 2000; 132(9):697-704.
Weiderpass E, Partanen T, Kaaks R et al. Occurrence, trends and environment etiology of pancreatic cancer. Scand J Work Environ Health 1998; 24(3):165-174.