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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2011, Número 3

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Rev Esp Med Quir 2011; 16 (3)


Avances de la genética de la preeclampsia

Valencia VEY, Canto CT, López HLB, Coral VRM, Canto CP

Idioma: Español
Referencias bibliográficas: 47
Paginas: 163-168
Archivo PDF: 246.28 Kb.


RESUMEN

La preeclampsia es una enfermedad específica del embarazo que se distingue por presión arterial elevada y proteinuria después de la vigésima semana de embarazo, en la cual los componentes etiológicos pueden variar dependiendo de la población. Se ha propuesto que existen factores genéticos predisponentes, ya que algunos estudios de asociación sugieren que los polimorfismos en genes que codifican para diversos factores implicados en la regulación de la presión arterial participan en el origen de este síndrome, como: MTHFR, AGT, ACE, GSTP1, eNOS, TNF-α e IL-6, entre otros. La mayor parte de estos estudios se ha llevado a cabo principalmente en poblaciones sajonas y asiáticas con resultados diversos, lo que sugiere que sí existe relación entre los polimorfismos y el grupo étnico. El objetivo principal de esta revisión es mostrar el papel que juegan los factores genéticos en la preeclampsia, y los estudios realizados en población mestiza mexicana.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstetric Gynecol 2000;183:S1-S22.

  2. Brown MA, Hague WM, Higgins J, Lowe S, et al. The detection, investigation and management of hypertension in pregnancy: executive summary. Aust N Z J Obstet Gynaecol 2000;40:133-138.

  3. Sibai BM. Diagnosis, controversies, and management of HELLP syndrome. Obstet Gynecol 2004;103:981-991.

  4. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003;102:181-192.

  5. Vollset SE, Refsum H, Irgens LM, Emblem BM, et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 2000;71:962-968.

  6. Frosst P, Blom HJ, Milos R, Goyette P, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.

  7. Kosmas IP, Tatsioni A, Ioannidis JP. Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and preeclampsia: a meta-analysis. J Hypertens 2004;22:1655-1662.

  8. Kobashi G, Yamada H, Asano T, Nagano S, et al. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet 2000;93:122-125.

  9. Dávalos IP, Morán MC, Martínez-Abundis E, González-Ortiz M, et al. Methylenetetrahydrofolate reductase C677T polymorphism and factor V Leiden variant in Mexican women with preeclampsia/eclampsia. Blood Cells Mol Dis 2005;35:66-69.

  10. Lisker R, Ramírez E, Pérez-Briceño R, Granados J, Babinsky V. Gene frequencies and admixture estimates in four Mexican urban centers. Hum Biol 1990;62:791-801.

  11. Canto P, Canto-Cetina T, Juárez-Velázquez R, Rosas- Vargas H, et al. Polimorphisims C-677T of 5,10 methylenetetrahydrofolate reductase and A-313G of glutathiones- transferase P1 are associated with preeclampsia in Maya-Mestizo women. Hypert Res 2008;31:1015-1019.

  12. Hubner RA, Houlston RS. MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations. Int J Cancer 2006;120:1027-1035.

  13. Zintzaras E, Koufakis T, Ziakas PD, Rodopoulou P, et al. A meta-analysis of genotypes and haplotypes of methylene tetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006;21:501-510.

  14. Morgan T, Ward K. New insights into the genetics of preeclampsia. Semin Perinatol 1999;23:14-23.

  15. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, et al. An insertion/deletion polymorphism in the angiotensin Iconverting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-1346.

  16. Zafarmand MH, Nijdam ME, Franx A, Grobbee DE, Bots ML. The angiotensinogen gene M235T polymorphism and development of preeclampsia/eclampsia: a meta-analysis and meta-regression of observational studies. J Hypertens 2008;26:1726-1734.

  17. Zafarmand MH, Franx A, Sabour S, van der Schouw YT, et al. The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study. Hypertens Res 2008;31:1299-1305.

  18. Bashford MT, Hefler LA, Vertrees TW, Roa BB, Gregg AR. Angiotensinogen and endothelial nitric oxide synthase gene polymorphisms among Hispanic patients with preeclampsia. Am J Obstet Gynecol 2001;184:1345-1350.

  19. Jenkins LD, Powers RW, Cooper M, Gallaher MJ, et al. Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women. Reprod Sci 2008;15:696-701.

  20. Podymow T, August P. Hypertension in pregnancy. Adv Chronic Kidney Dis 2007;14:178-190.

  21. Mello G, Parretti E, Gensini F, Sticchi E, et al. Maternal-fetal flow, negative events, and preeclampsia: role of ACE I/D polymorphism. Hypertension 2003;414:932-937.

  22. Medica I, Kastrin A, Peterlin B. Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 2007;131:115-126.

  23. Li H, Ma Y, Fu Q, Wang L. Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women. Hypertens Pregnancy 2007;26:293-301.

  24. Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998;179:1359-1375.

  25. Zusterzeel PL, Peters WH, De Bruyn MA, Knapen MF, et al. Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. Obstet Gynecol 1999;94:1033-1038.

  26. Zusterzeel PL, Visser W, Peters WH, Merkus HW, et al. Polymorphism in the glutathione S-transferase P1 gene and risk for preeclampsia. Obstet Gynecol 2000;96:50-54.

  27. Stanulla M, Schrappe M, Brechlin AM, Zimmermann M, Welte K. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Blood 2000;95:1222-1228.

  28. Dasgupta RK, Adamson PJ, Davies FE. Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma. Blood 2003;102:2345-2350.

  29. Hohaus S, Di Ruscio A, Di Febo A, Massini G, et al. Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. Clin Cancer Res 2005;11:2175-2179.

  30. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, et al. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-1204.

  31. Radomski MW, Palmer RM, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987;2:1057-1058.

  32. Wang Y, Gu Y, Zhang Y, Lewis DF. Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia. Am J Obstet Gynecol 2004;190:817-824.

  33. Sandrim VC, Palei AC, Sertorio JT, Cavalli RC, et al. Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. Mol Hum Reprod 2010;16:506-510.

  34. Landau R, Xie HG, Dishy V, Wood AJ, et al. No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia. Am J Hypertens 2004;17:391-394.

  35. Serrano NC, Casas JP, Díaz LA, Páez C, et al. Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. Hypertension 2004;44:702-707.

  36. Sandrim VC, Palei AC, Cavalli RC, Araújo FM, et al. eNOS haplotypes associated with gestational hypertension or preeclampsia. Pharmacogenomics 2008;9:1467-1473.

  37. Miyamoto Y, Saito Y, Nakayama M, Shimasaki Y, et al. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a –786T3C mutation associated with coronary spastic angina. Hum Mol Genet 2000;9:2629-2637.

  38. Wang XL, Sim AS, Wang MX, Murrell GA, et al. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett 2000;471:45-50.

  39. Hingorani AD, Liang CF, Fatibene J, Lyon A, et al. A common variant of the endothelial nitric oxide synthase (Glu298-- >Asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999;100:1515-1520.

  40. Yoon Y, Song J, Hong SH. Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms in coronary artery disease. Clin Chem 2000;46:1626-1630.

  41. Díaz-Olguín L, Coral-Vázquez RM, Canto-Cetina T, Canizales-Quinteros S, et al. Endothelial nitric oxide synthase gene haplotypes are associated with preeclampsia in Mayamestizo women. Dis Mark 2011;in press.

  42. Bauer S, Pollheimer J, Hartmann J, Husslein P, et al. Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab 2004;89:812-822.

  43. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. Tumour necrosis factor-alpha gene haplotype is associated with preeclampsia. Mol Hum Reprod 2005;11:437-440.

  44. Stonek F, Hafner E, Metzenbauer M, Katharina S, et al. Absence of an association of tumor necrosis factor (TNF)- alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. J Reprod Immunol 2008;77:85-90.

  45. Canto-Cetina T, Canizales-Quinteros S, de la Chesnaye E, Coral-Vázquez R, et al. Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-α gene in Maya-Mestizo women with preeclampsia. Hypertens Pregnancy 2007;26:283-291.

  46. Pfab T, Chen YP, Slowinski T, Richter CM, et al. Impact of genes related to immune tolerance and inflammation (tumour necrosis factor-alpha, interleukin-6) on blood pressure, protein excretion and oedema in pregnancy. J Hypertens 2005;23:2187-2191.

  47. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. Eur J Obstet Gynecol Reprod Biol 2006;128:175-179.




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