2001, Número 2
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Rev Mex Ing Biomed 2001; 22 (2)
Hipertermia electromagnética, una alternativa para el tratamiento del cáncer: antecedentes, aspectos físicos y biológicos
Vera HA, Chong QJE, Leija SL, Hernández MY, Marchal C
Idioma: Español
Referencias bibliográficas: 71
Paginas: 78-88
Archivo PDF: 327.12 Kb.
RESUMEN
El presente trabajo presenta una revisión histórica de la hipertermia electromagnética, así como también las bases biológicas y físicas de la hipertermia. Esta terapia consiste en la elevación de temperatura con el fin de destruir el tumor y es utilizada como tratamiento coadyuvante a la quimio y radio terapia ya que ésta potencia los efectos letales sobre las células cancerígenas. Al final de esta revisión se presentan las perspectivas de esta terapia.
REFERENCIAS (EN ESTE ARTÍCULO)
Elliot RS, Harrison WH et al. “Hyperthermia: Electromagnetic heating of deep-seated tumors”. IEEE Trans. Biomed Eng 1982; vol. BME-29: 61-64.
Strobbehn JW, Trembly BS et al. “Blood flow effects on the temperature distributions from an invasive microwave antenna array used in cancer therapy”. IEEE Trans. Biomed Eng 1982; vol. BME-29: 649-661.
Andersen JB, Baun A et al. “A hyperthermia system using a new type of inductive applicator”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 21-27.
Johnson RH, James JR et al. “New low-profile applicators for local heating of tissues”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 28-37.
Arcangeli G, Lombardini PP et al. “Tocusing of 915 MHz electromagnetic power on deep human tissues: A mathematical model study”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 47-52.
Lyons BE, Britt RH et al. “Localized hyperthermia in the treatment of malignant brain tumors using an interstitial microwave antenna array”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 53-62.
Atkinson WJ, Brezovich IA et al. “Usable frequencies in hyperthermia with thermal seed”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 70-75.
Stauffer PR, Cetas TC et al. “Observations on the use of ferromagnetic implants for inducing hyperthermia”. ITEE Trans. Biomed Eng 1984; vol. BME-31: 76-90.
Oleson JR. “A review of magnetic induction methods for hyperthermia treatment of cancer”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 91-97.
Ruggera PS, Kantor G. “Development of a family of R-F helical coil applicators which produce transversely uniform axially distributed heating in cy1indrical fat-muscle phantoms”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 98-106.
Matloubieh AY, Roemer RB et al. “Numerical simulation of magnetic induction heating of tumors with ferromagnetic seed implants”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 227-234.
Stauffer PR, Cetas TC et al. “Magnetic induction heating of ferromagnetic implants for inducing localized hyperthermia in deep-seated tumors”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 235-251.
Gandhi OP, DeFord JF et al. “Impedance method for calculation of power deposition patters in magnetically induced hyperthemia”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 644-651.
Strohbelm JW, Douple EB. “Hyperthemia and cancer therapy: A review of biomedical engineering contributions and challenges”. IEEE Trans. Biomed Eng 1984; vol. BME-31: 779-786.
Bini M, Ignesti A et al. “An unbalanced electric applicator for RF hyperthermia”. IEEE Trans. Biomed Eng 1985; vol. BME-32: 638-641.
Wait JR. “Terromagnetic implants in hyperthermia”. IEEE Trans. Biomed Eng 1985; vol. BME-32: 707-708.
Guerquin-Kern JL, Hagmann MJ et al. “Experimental characterization of helical coils as hyperthermia applicators”. IEEE Trans. Biomed Eng 1988; vol. BME-35: 4652.
Zhu XL, Gandhi OP. “Design of RF needle applicators for optimum SAR distributions in irregularly shaped tumors”. IEEE Trans. Biomed Eng 1988; vol. BME-35: 382-388.
Jones KM, Mechling JA et al. “SAR distributions for 915 MHz interstitial microwave antennas used in hyperthermia for cancer therapy”. IEEE Trans. Biomed Eng 1988; vol. BME-35: 851-857.
Tiberio CA, Raganella L et al. “The RF toroidal transformer as heat delivery system for regional and focused hyperthermia”. IEEE Trans. Biomed Eng 1988; vol. BME-35: 1077-1085.
Iskander MF, Tumeh AM. “Design optimization of interstitial antennas”. IEEE Trans. Biomed Eng 1989; 36: 238-246.
Furse CM, Iskander MF. “Three dimensional electromagnetic power deposition in tumors using interstitial antenna arrays”. IEEE Trans. Biomed Eng 1989; vol. BME-36: 977-986.
Ellinger DC, Chute FS et al. “Evaluation of a semi-cylindrical solenoid as an applicator for radio-frequency hyperthermia”. IEEE Trans. Biomed Eng 1989; vol. BME-36: 987-994.
Albert S. “Historical introduction to EMF health effects”. IEEE engineering in medicine and biology 1996; 15: 24-30.
Cavaliere R, Ciocatto E, Giovanella B, Heidelberger C, Johnson R, Moricca G, Rossi-Fanelli A. “Selective heat sensitivity of cancer celis (biochemical and clinical studies), Cancer” 1967; 20: 1351-1381.
Czerski P. “Microwave effects on the blood forming system with particular reference to the lymphocyte. Ann NY Acad Sci 1975; 247: 232.
Dietzel F. “Tumor und temperature. Urban and Schwarzenberg. Munich and Berlin. 1975.
Fischer E, Solomon S. “Physiological responses to heat and cold” in therapeutic heat and cold, Licht S, Ed. New Haven Conn.: Licht, 1965; sec. 4: 126-169.
Guy A. “History of biological effects on medical applications of microwave energy”. IEEE trans MTTS, 1984; 32(9): 1182-1199.
Hahn G. Hyperthermia and cancer. Plenum Press. NY. 1982.
Hahn G. “Metabolic aspects of the role of hyperthermia in mammalian cell inactivation and their possible relevance to cancer treatment”. Cancer Res 1974; 34: 3117-3123.
Hardy J. “Thermal radiation, pain and injury”, in therapeutic heat and cold, S. Licht, Ed. New Haven, Conn. Licht, 1965; sec. 5: 170-195.
Kim S, Kim J, Ha1m E. “Enhanced killing of hypoxic tumor cells by hyperthermia”. Br J Radiol 1975; 48: 872-874.
Kottke F. “Heat in pelvic diseases”, in Therapeutic Heat and Cold, S. Licht, Ed. New Haven, Vconn. Licht, 1965; sec: 18: 474-490.
Lehmann J, Hohlfeld R. “Der gewebestoffwechsel nach ultraschall und wärmeeinwirkung”, Strahlentherapie, 1965; 87: 544-549, 1952. en Licht.
Lehmann J, Brunner G, Stow R. “Pain thresholds measurements after therapeutic application of ultasonic microwave and infrared”, Arch Phys Med 1958; 39: 560-565.
Lehmann J. “Diathermy” in handbook of physical medicine and rehabilitation, Krusen, Kottke, Elwood, Eds. Philadelphia, Pa.: Saunders, 1971; sec. 11: 273-345.
Licht S. “History of therapeutic heat,” in Therapeutic heat and cold, S. Licht, Ed New Heaven, Conn., Licht., 1965; sec. 6: 196-231.
Overgaard K, Overgaard V. Investigations on the possibility of a thermic tumor therapy”. Eur J Cancer 1972; 8: 65-78.
Schliephake E. “General principles of thermotherapy”, in Therapeutic S. Heat., Licht, 1965; sec 4: 126-169.
Schwan HP. “History of the Genesis and development of the study of effects of low energy electromagnetic fíelds”, in Biological Effects and dosimetry of noionizing radiation, Grandolfo M, Michaelson. Publishing, 1983.
Stitt J. “Fever versus hyperthermia”. Fed Proc 1979; 38: 39-43.
Strom R, Rossi-Fanelli C, Mondovi B. “Biochemical aspects of heat sensitivity of tumor cells”, in Selective heat sensitivity of cancer cells (Rossi-Fanelli A et al). Springer-Verlag, Berlin, Heidelberg, and New York: 7-35.
Suit H, Shwayder M. “Hyperthermia: potential as an Anti-Tumor Agent”. Cancer 1974; 34: 122-129.
Thuery J. “Microwaves, industrial, scientific, and medical applications. Artech House” Inc. USA 1992.
Wiktor-Jedrzejczak W, Ahmed A, Sell K, Czerski P, Leach W. “Microwaves induce an increase in the frequency of complement receptor-bearing lymphoid spleen cells in mice.” J Immunol 1977; 118: 1499 en MOSELEY 1988; Non Ionizing Radiation.
Zimmer RM, Ecker A, Popovic VP. “Selective electromagnetic heating of tumors in animals in deep hypothermia”, IEEE Trans. Microwave theory tech. (Special Issue on Biological Effects of Microwaves), MTT-1971; 19: 238-245.
Moseley H. Non-ionising radiation. IOP Publishing. Great Britain 1988.
Krusen F, Herrick UF, Leden K, Wakim K. “Microkymatotherapy: preliminay report of experimental studies of the heating effect of microwaves in living tissues”. In: Proceedings of staff meetings. Mayo, Mayo Clinic 1947; 22: 209-224.
HSWAN. “Thermoregulation and bioenergetics”, Elsevier Publishing Co. Amsterdam. 1974: 330-331.
Dewey WC, Freeman ML et al. “Cell biology of hyperthermia and radiation”. Radiation biology in cancer research. Raven Press 1980: 589-623. New York.
Robinson JE, McCulloch D, Edelsack EA. “Microwave heating of malignant mouse tumors heating of malignant phantom systems”, Journal of microwaves power, 1976; 11(2): 87-98.
Tell R, Harlen F. “A review of selected biological effects and dosimetric data useful for development of radiofrequency safety standards for human exposure”. J Microwave Power 1979; 4: 405.
Christensen DA, Durney CH. “Hyperthermia production for cancer therapy: a review of fundamentals and methods”, journal of microwave power, 1981; 16(2): 89-105.
Guerquin-Kem JL, Palas L, Priou A, Gautherie M. “Local hyperthermia using microwave for therapeutic purposes experimental studies of various applicators”, Journal of microwave power, 1981; 16(3 y 4): 05-311.
Foster KR, Schepps JL. “Dielectric properties of tumor and normal tissues at radio through microwave frequencies”, Journal of Microwave Power 1981; 16(2): 107-119.
Mazeron J, Locoche T, Maugis A. Techinques d’rradiation des cancers. Ed. Vigot. France. 1994.
Percy JF. Heat in the treatment of carcinoma in the uterus. Surgery Ginec Obstet 1916; 22: 77-79.
Valentino A. “Diseño y construcción de la instrumentación básica para la experimentación de efectos por radiación electromagnética en material biológico dentro del intervalo de 4 a 8 Ghz”. Tesis de maestría. CINVESTAV - IPN. Mexico. 1996.
Seegenshcmiedt MH, Fessenden P, Vemon CC. Thermo-radiotherapy and thermochemotherapy: Biology, physiology and physics, 1, Springer, Alemania, 1995.
Vera A. “Contribution a l’étude d’un systéme d’hyperthermie profonde en cancerologie: Automatisation du traitement du signal, modelisation, validation de la distribution et de l’absorption du champ electrique a 27.12 MHz dans les tissus simulés”, Tesis doctoral, INPL-CRAN, Francia, 1999.
Jouvie F. “Calcul du champ rayonne par des reseaux d’applicateurs por hyperthermie profonde”, Tesis doctoral, Universidad Paul Sabatier, Toulouse, Francia, 1984.
VanRhoon GC. Radiofrequency hyperthermia systems: Experimental and clinical assesment of the feasibility of radiofrequency hyperthermia systems for loco-regional deep heating, Delft University Press, Países Bajos, 1994.
COMAC BME, Treatment planning and modelling in hyperthermia, Tor Vergata Medical Physics Monographs Series, Roma, 1992.
Bourdrel N. “L’hyperthermie en cancérologie”, Thése de L’université de Nantes, 1990.
Tekieli P. “Définition d’un systéme d’hyperthermie profonde anticancéreuse induite par couplage de deux guides d’ondes a 27.12 MHz: Aspects modélisation, antenne et adaptation automatique d’impédance”, Nancy, Institut National Polytechnique de Lorraine, 1996.
Niederst C. “Mise au point et intégration en clinique d’un programme prévisionnel de calcul de la répartition du champ électrique et des températures induites par des applicateurs électromagnétiques extemes”, Université Paul Sabatier de Toulouse, 1997.
Bourdrel N. “L’hyperthermie en cancérologie”, Tesis de la Universidad de Nantes, 1990.
Streffer C. “Biological basis of thermotherapy: with special reference to oncology”. Springer Berlin, 1990: 1-71.
Bowler K, Duncan CJ, Gladwell RT, David TF. “Cellular heat injury”, Comp biochem Physic, 1973; 45: 441-450.
Lin PS, Turi A, Kwock L. “Hyperthermie effect on microtubule organization”, Nat Cancer Inst Monogr 1982; 61: 63-67.