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Colegio de Medicina Interna de México.

2011, Número 4

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Med Int Mex 2011; 27 (4)


La farmacocinética poblacional y su importancia en la terapéutica

Barranco GLM, Neri SJC, León MH, Carrasco PMC, Flores MFJ, Patiño CSI

Idioma: Español
Referencias bibliográficas: 43
Paginas: 370-377
Archivo PDF: 431.50 Kb.


RESUMEN

La farmacocinética poblacional tiene su principal aplicación en el estudio del comportamiento de los fármacos, mediante la estimación de valores medios de los parámetros farmacocinéticos en un grupo de individuos o una población de pacientes; así como la variabilidad interindividual asociada con dichos parámetros a partir de datos obtenidos de pacientes de la práctica clínica rutinaria. La variabilidad de la respuesta farmacológica se basa en diversas características relacionadas con la situación fisiopatológica de los pacientes, como: edad, género, peso, factores genéticos, factores ambientales, estados patológicos, situación clínica, etc. Los modelos poblacionales proporcionan una guía inicial para desarrollar regímenes de dosificación con el fin de alcanzar y mantener una determinada concentración plasmática en cada paciente. El propósito de este artículo de revisión es conocer las aplicaciones de los estudios de farmacocinética poblacional e identificar las características intrínsecas y extrínsecas que puedan influir en los parámetros farmacocinéticos de los fármacos analizados.


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