Hueletl-Soto ME, Rodríguez-Manzo G

Idioma: Español
Referencias bibliográficas: 41
Paginas: 89-95
Archivo PDF: 78.53 Kb.

RESUMEN

La respuesta eyaculatoria se integra a nivel de la médula espinal y, recientemente, se demostró que está controlada por un generador central de patrones: el generador espinal de la eyaculación. El tratamiento farmacológico crónico frecuentemente tiene entre sus efectos adversos afectar la respuesta sexual. Las disfunciones sexuales asociadas al tratamiento antidepresivo incluyen con frecuencia alteraciones en la respuesta eyaculatoria. En esta revisión se presenta información novedosa que muestra que algunos de estos tratamientos alteran el funcionamiento del generador espinal de la eyaculación, por lo que es posible que estas alteraciones jueguen un papel en las disfunciones eyaculatorias asociadas al tratamiento crónico con antidepresivos. La información que surge del análisis del funcionamiento del generador espinal de la eyaculación es relevante para el diseño de nuevas estrategias terapéuticas para el tratamiento de las disfunciones eyaculatorias.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Newman H, Reiss H, Northurp JD. Physical basis of emission, ejaculation, and orgasm in the male. Urology 1982; 19(4): 341-350.

2. Hull EM, Rodríguez-Manzo G. Male sexual behavior. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, Brain and Behavior. 2nd ed. Vol.1. San Diego; Academic Press, 2009: 5-65.

3. Carro-Juárez M, Rodríguez-Manzo G. The spinal pattern generator for ejaculation. Brain Res Rev 2008; 58(1): 106-120.

4. Peeters M, Giuliano F. Central neurophysiology and dopaminergic control of ejaculation. Neurosci Biobehav Rev 2008; 32(3): 438-453.

5. Coolen LM, Allard J, Truitt WA, McKenna KE. Central control of ejaculation. Physiol Behav 2004; 83(2): 203-215.

6. Carro-Juárez M, Cruz SL, Rodríguez-Manzo G. Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation. Brain Res 2003; 975(1-2): 222-228.

7. Grillner S. Neurobiological bases of the rhythmic motor acts in vertebrates. Science 1985; 228(4696): 143-149.

8. Orbach J. Spontaneous ejaculation in the rat. Science 1961; 134(3485): 1072-1073.

9. Truitt WA, Coolen LM. Identification of a potential ejaculation generator in the spinal cord. Science 2002; 297(5586): 1566-1569.

10. Truitt WA, Shipley MT, Veening JG, Coolen LM. Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci 2003; 23(1): 325-331.

11. Xu C, Giuliano F, Yaici ED, Conrath M, Trassard O, Benoit G, Verge D. Identification of lumbar spinal neurons controlling simultaneously the prostate and the bulbospongiosus muscles in the rat. Neuroscience 2006; 138(2): 561–573.

12. Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, Bass KI, Donahue RM, Jamerson BD. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 2002; 63(4): 357-366.

13. Guze BH, Gitlin M. New antidepressants and the treatment of depression. J Fam Pract 1994; 38(1): 49-57.

14. Bettocchi C, Verze P, Palumbo F, Arcaniolo D, Mirone V. Ejaculatory disorders: pathophysiology and management. Nat Clin Pract Urol 2008; 5(2): 93-103.

15. De Leo D, Magni G. Sexual side effects of antidepressant drugs. Psychosomatics 1983; 24(12): 1076-1082.

16. Montgomery SA, Baldwin DS, Riley A. Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 2002; 69(1-3): 119-140.

17. Rothschild AJ. Sexual side effects of antidepressants. J Clin Psychiatry 2000; 61 (Suppl 11): 28-36.

18. Smith S. Drugs that cause sexual dysfunction. Sex dysfunctions 2007; 111-114.

19. Clayton AH, Montejo AL. Major depressive disorder, antidepressants, and sexual dysfunction. J Clin Psychiatry 2006; 67 (Suppl 6): 33-37.

20. Ferguson JM. The effects of antidepressants on sexual functioning in depressed patients: a review. J Clin Psychiatry 2001; 62(3): 22–34.

21. Hsu JH, Shen WW. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry Med 1995; 25(2): 191-201.

22. Coleman CC, King BR, Bolden-Watson C, Book MJ, Segraves RT, Richard N, Ascher J, Batey S, Jamerson B, Metz A. A placebo-controlled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clin Ther 2001; 23(7): 1040-1058.

23. Schweitzer I, Maguire K, Ng C. Psychiatry. Sexual side-effects of contemporary antidepressants: review. Aust N Z J 2009; 43(9): 795-808.

24. Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, Johnston JA. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry 2005; 7(3): 106-113.

25. Maas JW. Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression. Arch Gen Psychiatry 1975; 32(11): 1357-1361.

26. Marson L, McKenna KE. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res 1992; 88(2): 313-20.

27. Carro-Juárez M, Rodríguez-Manzo G. Exhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT. Behav Brain Res 2001; 118(2): 161-168.

28. Stafford AS, Tang K, Coote HJ. Activation of lumbosacral 5-HT2C receptors induces bursts of rhythmic activity in sympathetic nerves to the vas deferens in male rats. Br J Pharmacol 2006; 148(8): 1083-1090.

29. Carro-Juárez M, Rodríguez-Manzo G. alpha-Adrenergic agents modulate the activity of the spinal pattern generator for ejaculation. Int J Impot Res 2006; 18(1): 32-38.

30. Stafford SA, Coote JH. Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetized rats. Br J Pharmacol 2006; 148(4): 510-516.

31. Carro-Juárez M, Rodríguez-Manzo G. Sensory and motor aspects of the coital reflex in the spinal male rat. Behav Brain Res 2000; 108(1): 97-103.

32. Hueletl-Soto ME, Carro-Juárez M, Rodríguez-Manzo G. Fluoxetine chronic treatment inhibits male rat sexual behavior by affecting both copulatory behavior and the genital motor pattern of ejaculation. J Sex Med 2011; doi: 10.1111/j.1743-6109.2011.02339.

33. Cantor JM, Binik YM, Pfaus JG. Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin. Psychopharmacology 1999; 144(4): 355-362.

34. Frank, JL, Hendricks, SE, Olson CH. Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. Pharmacol Biochem Behav 2000; 66(2): 337-342.

35. Taylor G, Bardgeti IM, Csernansky J, Early T, Haller J, Scherrer J, Womack S. Male reproductive systems under chronic fluoxetine or trimipramine treatment. Physiol Behav 1996; 59(3): 479-485.

36. Vega-Matuszcyk J, Larsson K, Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 1998; 60(2): 527-532.

37. Yells DP, Prendergast MA, Hendricks SE, Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav 1994; 49(1): 121-127.

38. Hueletl-Soto ME, Carro-Juárez M, Rodríguez-Manzo G. DMI-induced sexual effects in male rats: analysis of DMI’s acute and chronic actions on copulatory behavior and on the genital motor pattern of ejaculation. Pharmacol Biochem Behav 2010; 94(3): 423-430.

39. Sukoff-Rizzo SI, Schechter LE, Rosenzweig-Lipsson S. A novel approach for predicting antidepressant-induced sexual dysfunction in rat. Psychopharmacology 2008; 195: 459-467.

40. Demyttenaere K, Huygens R. Painful ejaculation and urinary hesitancy in association with antidepressant therapy: relief with tamsulosin. Eur Neuropsychopharmacol 2002; 12(4): 337-341.

41. Yang BK, Donatucci CF. Drugs that affect male sexual function. In: Mulcahy JJ, ed. Male sexual function: a guide to clinical management, 2nd ed. Current Clinical Urology Series. Totowa, NJ; Humana Press Inc., 2006: 155-193.