2000, Número 4
Enfermedad celiaca (Conceptos actuales)
Pichardo BR, Méndez-Sánchez N
Idioma: Español
Referencias bibliográficas: 38
Paginas: 124-130
Archivo PDF: 121.17 Kb.
RESUMEN
En los últimos años los conceptos acerca de la enfermedad celiaca (EC), así tanto como la patogenia han cambiado significativamente. Esto como resultado de la utilización de pruebas serológicas específicas y el desarrollo de los estudios de biología molecular. La epidemiología, así como la presentación clínica de los pacientes ha sido reconsiderada radicalmente. La enfermedad celiaca es una entidad de gran interés para los clínicos e investigadores ya que representa un modelo de interacción entre factores ambientales, genéticos e inmunológicos. El objetivo de esta presentación es la revisión de los factores etiológicos de la enfermedad, así como la epidemiología.
REFERENCIAS (EN ESTE ARTÍCULO)
Thomas C. On the celiac affection. In: Major RH, ed. Classic descriptions of disease. Springfiend, IL: Charles C. Thomas, 1945; 600-601.
Truelove S, Reynell P. Celiac disease and tropical sprue. In: Disease of the digestive system. Oxford, England: Blackwell, 1972; 289-315.
Gee S. On the celiac affection. St Barth Hosp Res 1888; 24: 17-20.
Bennett T, Hunter D, Vaugham J. Celiac disease persisting into adulthood. QJM 1932; 1: 603-607.
Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119: 234-242.
Tracone R, Greco L, Auricchio S. Gluten-sensitive enteropathy. Pediatric Clinics of North America 1996; 43: 355-373.
Polanco I, Jasisnski C, de Rosa S. Celiac disease in Argentina and Uruguay. Dyn Nutr Res 1992; 2: 57.
Rubin C, Brandborg LL, Phelps PC, Tylor HC. Studies of celiac disease. Part I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology 1960; 38: 28-38.
Hed J, Leden G, Ottonson E. IgA anti-gliadin antibodies and jejunal mucosal lesions in healthy blood donors. Lancet 1986; 2: 215.
Auricchio S, Mazzacca G, Tosi R. Celiac disease as a familial condition: Identification of asymptomatic celiac patients within family groups. Gastroenterol Int 1988; 1: 25.
Tosi R, Vismara D, Tanigaki N. Evidence that celiac disease is primarily associated with a DC locus allelic specificity. Clin Immunol Immunopathol 1983; 28: 395-404.
Sallid LM, Markussen G, Ek J. Evidence for a primary association of celiac disease to a particular HLA – DQ a/b heterodimer. J Exp Med 1989; 169: 345-50.
Mantovani V, Corazza Gr, Bragliani M. Asp57-negative HLA DQbeta chain and DQA1*0501 allele are essential for the onset of DQw2-positive and DQ2w2-negative celiac disease. Clin Exp Immunol 1993; 91: 153-156.
Spurkland A, Sollid LM, Polanco I. HLA-DR and DQ genotypes of celiac disease patients serologically typed to be non DR3 or non DR5/7. Human Immunol 1992; 35: 188-192.
Lundin KE, Scott H, Hansen TS, Fausa. Gliadin-specific, HLA-DQ (A1*0501, B1*0201) restricted T cells from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178: 187-196.
Roschmann E, Wienker TF, Gerok W, Volk BA. T-cell receptor variable genes and genetic susceptibility to celiac disease: an association and linkage study. Gastroenterology 1993; 105: 1790-1796.
Halstensen TS, Hvatum M, Scott H. Association of subepithelial deposition of activated complement and immunoglobulin G and M response to gluten in celiac disease. Gastroenterology 1992; 102: 751-759.
Halstensen TS, Scott H, Brandtzaeg P. Intraepithelial T cells of the TCR gammadelta CD8 - and Vdelta1/Jdelta1 + phenotypes are increased in coeliac disease. Scand J Immunol 1989; 30: 665-672.
Spencer J, Isaacson PG, Diss TC. Expression of disulfide-linked and non-disulfide-linked forms of the cell receptor gammadelta heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 1989; 19: 1335-1338.
Holm K, Maki M, Savilahti E. Intraepithelial gammadelta T-cell-receptor lymphocytes and genetic susceptibility to celiac disease. Lancet 1992; 339: 1500-1503.
Kutlu T, Brousse N, Rambaud C. N T cell receptor (TCR) alphabeta + but not of TcR gammadelta + intraepithelial lymphocytes with the grade of villous atrophy in celiac patients on a long-term normal diet. Gut 1993; 34: 208-214.
Halstensen TS, Brandtzaeg P. Activated T lymphocytes in the celiac lesion: Non-proliferative activation (CD25) of CD4 + alphabeta cells in the lamina propria but proliferation (Ki-67) of alphabeta and gammadelta cells in the epithelium. Eur J Immunol 1993; 23: 505-510.
Marsh MN. Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten sensitivity. (“Celiac Sprue”) Gastroenterology 1992; 102: 330-354.
Kett K, Scott H, Fausa O. Secretory immunity in celiac disease: Cellular expression of immunoglobulin A subclass and joining chain. Gastroenterology 1990; 99: 386-92.
Wood GM, Howdle PD, Trejdosiewicz LK et al. Jejunal plasma cells and in vitro immunoglobulin production in adult coeliac disease. Clin Exp Immunol 1987; 69: 123-132.
O’Mahony S, Vestey JP, Ferguson A. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in celiac disease. Lancet 1990; 335: 1487-1490.
Fais S, Maiuri L, Pallone F. Gliadin-induced changes in the expression of MHC-class II antigens by human small intestinal epithelium. Organ culture studies with celiac disease mucosa. Gut 1992; 33: 472-475.
Cox GJ Jr, McDonald GB. Graft-versus-host disease of the intestine. Springer Semin Immunopathol 1990; 12: 283-299.
Maiuri L, Troncone R, Coletta S. A-Gliadin 31-43 sequence activates intestinal cell-mediated immunity in the celiac mucosa. J Pediatr Gastroenterol Nutr 1993.
Bland PW, Warren LG. Antigen presentation by epithelial cells of the rat small intestine: I. Kinetics, antigen specificity and blocking by anti-Ia antisera. Immunology 1986; 58: 1-7.
Sturgess R, Day P, Ellis HJ. Wheat peptide challenge in celiac disease. Lancet 1994; 343: 758-61.
Ferguson A, Arranz E, O’Mahony S. Clinical and pathological spectrum of celiac disease-active, silent, latent, potential. Gut 1993; 34: 150-151.
Holm K, Savilahti E, Koskimies S. Immunohistochemical changes in the jejunum in first-degree relatives of patients with celiac disease and the coeliac disease marker DQ genes. HLA class II antigen expression, interleukin 2 receptor positive cells and dividing crypt cells. Gut 1994; 35: 55-60.
Magnusson KE, Stjernstrom I. Mucosal barrier mechanisms: Interplay between secretory IgA (SIgA), IgG and mucins on the surface properties and association of salmonellae with intestine and granulocytes. Immunology 1982; 45: 239-248.
Shibahara T, Sato N, Waguri S et al. The fate of effete epithelial cells at the villus tips of the human small intestine. Arch Histol Cytol 1995; 58: 205-219.
Kalmar JR, Arnold RR. Killing of Actinobacillus actinomycetemcomitans by human lactoferrin. Infect Immun 1998; 56: 2552-2557.
Laible NJ, Germaine GR. Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: Inhibition by chitin oligosaccharides. Infect Immun 1995; 48: 720-728.
Tenovuo J, Kurkijarvi K. Immobilized lactoperoxidase as a biologically active and stable form of an antimicrobial enzyme. Arch Oral Biol 1981; 26: 309-314.