2001, Número 4
Aclaramiento ganglionar. Técnicas e indicaciones
Pichardo-Bahena R, Barredo PBA, Méndez-Sánchez N
Idioma: Español
Referencias bibliográficas: 18
Paginas: 117-118
Archivo PDF: 33.96 Kb.
RESUMEN
La disección de los ganglios linfáticos (GL) peritumorales en las neoplasias epiteliales como las originadas en colon y mama, es una parte muy importante, es la estadificación patológica y clínica de estos pacientes. La identificación de los GL es un proceso arduo y difícil, donde los GL de menos de 0.5 cm pueden pasar inadvertidos y pudieran contener metástasis. Por estos motivos se han desarrollado diferentes técnicas de mejoramiento visual de los GL, mismas que se han denominado sustancias de “aclaramiento ganglionar”. En este artículo se comentan las diferentes técnicas, así como sus indicaciones y aplicaciones.
REFERENCIAS (EN ESTE ARTÍCULO)
Jass JR, Miller K, Northover JM. Fat clearance method versus manual dissection of lymph nodes in specimens of rectal cancer. Int J Colorrectal Dis 1986; 1: 155-6.
Mainprize KS, Hewavisinthe J, Savaje A, Mortensen M, Warren BF. How many lympho nodes to stage colorectal carcinoma? J Clin Pathol 1998; 51: 165-166.
Caplin S, Cerottini J-P, Bosman FT, Constanda MT, Givel J-C. For patients with Dukes’ B (TNM Stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. Cancer 1998; 83: 666–672.
Fielding LP, Arsenault PA, Chapius PH et al. Clinicopathological staging for colorectal cancer: an International Documentation System (IDS) and an international comprehensive anatomical terminology (ICAT). J Gastroenterol Hepatol 1991; 6: 325–344.
Goldstein NS, Sanford W, Coffey M, Layfield LJ. Lymph node recovery from colorectal resection specimens removed for adenocarcinoma: trends overtime and a recommendation for a minimum number of lymph nodes to be recovered. Am J Clin Pathol 1996; 106: 209–216.
Hernanz F, Revuelta S, Redondo C, Madrazo C, Castillo J, Gómez-Fleitas M. Colorectal adenocarcinoma: quality of the assessment of lymph node metastases. Dis Colon Rectum 1994; 37: 373–377.
Maurel J, Launoy G, Grosclaude P et al. Lymph node harvest reporting in patients with carcinoma of the large bowel: a French population based study. Cancer 1998; 82: 1482–1486.
Scott KWM, Grace RH. Detection of lymph node metastases in colorectal carcinoma before and after fat clearance. Br J Surg 1989; 76: 1165–1167.
Lewin KJ, Riddell RH, Weinstein WM. Gastrointestinal pathology and its clinical implications. New York, NY: Igaku-Shoin; 1992.
Cawthorn SJ, Gibbs NM, Marks CG. Clearance technique for the detection of lymph nodes in colorectal cancer. Br J Surg 1986; 73: 58-60.
Haboubi NY, Abdalla SA, Amini S et al. The novel combination of fat clearance and immunohistochemistry improves the prediction of outcome of patients with colorectal carcinomas: a preliminary study. Int J Colorrectal Dis 1998; 13: 99–102.
Herrera L, Villarreal JR. Incidence of metastases from rectal adenocarcinoma in small lymph nodes detected by a clearing technique. Dis Colon Rectum 1992; 35: 783–788.
Kotanagi H, Fukuoka T, Shibata Y et al. The size of regional lymph nodes does not correlate with the presence or absence of metastases in lymph nodes in rectal cancer. J Surg Oncol 1993; 54: 252–254.
Rodríguez-Bigas MA, Maamoun S, Weber TK, Penetrante RB, Blumenson LE, Petrelli NJ. Clinical significance of colorectal cancer: metastases in lymph nodes, 5 mm in size. Ann Surg Oncol 1996; 3: 124–130.
Wade DS, Herrera L, Castillo NB, Petrelli NJ. Metastases to the lymph nodes in epidermoid carcinoma of the anal canal studied by a clearing technique. Surg Gynecol Obstet 1989; 169: 238–242.
Steele RJ, Forrest AP, Gibson T, Stewart HJ, Chetty U. The efficacy of lower axillary sampling in obtaining lymph node status in breast cancer: a controlled randomized trial. Br J Surg 1985; 72: 368-9.
Scott KW, Grace RH. Detection of lymph node metastases in colorectal carcinoma before and after fat clearance. Br J Surg 1989; 76: 1165-7.
Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix. Arch Pathol Lab Med 2000; 124: 1016–1025.