Calderón-Guzmán D, Hernández-García E, Barragán-Mejía G, Santamaría ÁD, Juárez-Jacobo EA, Segura-Abarca ML

Idioma: Español
Referencias bibliográficas: 35
Paginas: 14-19
Archivo PDF: 123.85 Kb.

RESUMEN

La aspirina (ASA) es el anti-inflamatorio no esteroidal mas ampliamente distribuido y con más frecuencia usado para combatir el dolor. En la catualidad se le atribuyen alteraciones del balance oxidante y antioxidante, aumentando el efecto analgésico si está se combina con sustancias antioxidantes exógenas. Objetivos: medir parámetros indicadores de estrés oxidante en cerebro de ratas adultas con dosis única de ASA y taurina. Material y métodos: se utilizaron ratas adultas macho con los siguientes tratamientos en una sola dosis: grupo I control, NaCl 0.9%; grupo II, ASA; grupo III, taurina; grupo IV, ASA+taurina. El ASA (20 mg/kg) y taurina (100 mg/kg) se administraron por vía i.p. A las dos horas de la administración, fueron sacrificadas y se midieron en homogenado de cerebro los niveles de peroxidación de lípidos (Tbars), glutatión (GSH), ácido 5-hidroxi-ildol acético (5-HIAA), y la actividad de Na⁺, K⁺ ATPasa, mediante métodos de espectrofotometría y fluorescencia. Resultados: los niveles de Tbars se incrementaron significativamente en todos los grupos experimentales (p‹0.05), la concentración de 5-HIAA y GSH disminuyeron significativamente en todos los grupos experimentales (p‹0.05), la actividad de Na⁺, K+ ATPasa y ATPasa total disminuyeron sólo en el grupo que recibió taurina (p‹0.05), todos con respecto al grupo control. Conclusión: en base a los resultados se sugiere que el consumo de ASA y taurina alteran el metabolismo serotonérgico e inducen estrés oxidante en cerebro.

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