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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2010, Número 3

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Rev Esp Med Quir 2010; 15 (3)


Distrofias musculares en México: un enfoque clínico, bioquímico y molecular

Coral VRM, López HLB, Ruano CLÁ, Gómez DB, Fernández VF, Bahena ME

Idioma: Español
Referencias bibliográficas: 28
Paginas: 152-160
Archivo PDF: 261.34 Kb.


RESUMEN

Las distrofias musculares son un conjunto de enfermedades que se distinguen por debilidad progresiva y desgaste muscular que generalmente provocan discapacidad. En conjunto, se originan por defectos en genes que codifican para proteínas sumamente importantes para el funcionamiento de las células musculares, las cuales se pueden dividir en proteínas de matriz extracelular, de membrana y de citoesqueleto. El estudio de caracterización molecular y funcional de estas proteínas ha inducido múltiples avances en el diagnóstico y tratamiento de las distrofias musculares; de igual manera, ha contribuido al conocimiento de los mecanismos celulares y moleculares que intervienen en el origen de estas enfermedades.


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