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2002, Número 4

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Med Sur 2002; 9 (4)


Perfusión aislada de extremidad. Una alternativa a la amputación en tumores avanzados por melanoma, sarcomas y otros tumores irresecables de las extremidades

Martínez SH, Herrera GA, Aguilar PJL, Garza SJG

Idioma: Español
Referencias bibliográficas: 66
Paginas: 148-155
Archivo PDF: 149.66 Kb.


RESUMEN

La perfusión aislada de extremidad es una técnica utilizada desde 1959 en el tratamiento del melanoma maligno con resultados satisfactorios en las lesiones en tránsito. Con los diferentes esquemas de drogas para perfusión se han obtenido respuestas globales que oscilan del 80% al 100%, lo que ha permitido ampliar las indicaciones en melanoma a los pacientes con lesiones primarias irresecables o concomitantes a enfermedad metastásica a distancia. Con estos resultados y la aparición en el mercado del factor de necrosis tumoral se extendió su uso a otras neoplasias. En sarcomas de tejidos blandos de las extremidades se han obtenidos respuestas satisfactorias en el 95% de los casos, con la mejor respuesta patológica completa jamás obtenida por otro método neoadyuvante. Actualmente el uso de la perfusión aislada de extremidad permite el salvamento de una extremidad en 90% de los casos.


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