medigraphic.com
ISSN 2992-8036 (Digital)
ISSN 2306-4102 (Impreso)
Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología

2011, Número 2

<< Anterior Siguiente >>

Acta Ortop Mex 2011; 25 (2)


Comparación del uso intraarticular postoperatorio de RV023 y hialuronato G-F20 en artroscopía de rodilla. Experiencia en el Hospital Español de México

Valles-Figueroa JFJ, Ambrosio-Salgado J, Suárez-Ahedo CE, Rueda-Villarón O

Idioma: Español
Referencias bibliográficas: 47
Paginas: 119-125
Archivo PDF: 567.20 Kb.


RESUMEN

Desde hace dos décadas la cirugía artroscópica ha revolucionado el tratamiento de las lesiones traumáticas agudas de la rodilla, logrando que el paciente se reincorpore a sus actividades de la vida diaria en un breve lapso de tiempo; in embargo, existen factores que retrasan esta meta como el sangrado intraarticular postquirúrgico, la inflamación y el dolor que limitan la movilidad inmediata de la articulación. En el presente estudio se hace un análisis de dichos factores y sus procesos fisiopatológicos, lo que nos llevó a la formulación de un preparado para uso intraarticular llamado RV023. Se presenta el reporte de un estudio original, prospectivo, longitudinal en el que se evalúan los resultados funcionales del preparado RV023 en una muestra de 60 pacientes cuyos criterios de selección fueron dolor de rodilla de 2 años de evolución que no responden al tratamiento con AINES y cuya resonancia magnética muestra lesión condral grado I de Outerbridge, sin evidencia de lesión ligamentaria, meniscal o fractura y que fueron sometidos a cirugía artroscópica de rodilla. Existe una diferencia significativa en la función articular de los sujetos tratados con el preparado en comparación con aquéllos en que éste no se empleó. Las curvas de restablecimiento de la función articular de los sujetos en que se empleó el preparado son prácticamente simétricas a los sujetos control facsanos. Por otra parte, no se registró ninguna reacción alérgica, colateral o efecto indeseable, por lo que concluimos que la seguridad y los beneficios que ha presentado en modelos de experimentación el preparado RV023, son suficientes para sustentar su uso en humanos.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Waddell DD, Bert JM: The use of hyaluronan after arthroscopic surgery of the knee. Arthroscop Rel Surg 2010; 26(1): 105-11.

  2. Metcalf RW: Operative arthroscopy of the knee. AAOS Instr Course Lect 1981; 30: 357.

  3. McGinty JB, Matza RA: Arthroscopy of the knee, evaluation of an out-patient procedure under local anesthesia. JBJS 1978; 60-A: 787.

  4. The memories of the International Arthroscopy Association Meeting, Philadelphia, PA.980.

  5. Rasmussen S, Larsen AS, Thomsen ST, Kehlet H: Intraarticular glucocorticoid, bupivacaine and morphine reduces pain, inflammatory response and convalescence after arthroscopic meniscectomy. Pain 1998; 78(2):131-4.

  6. Chan ST: Intraarticular morphine and bupivacaine for pain relief after therapeutic arthroscopic knee surgery. Singapore Med J 1995; 36(1): 35-7.

  7. Lundin O, Rydgren B, Sward L, Karlsson J: Analgesic effects of intra-articular morphine during and after knee arthroscopy: a comparison of two methods. Arthroscopy 1998; 14(2): 192-6.

  8. De Andres J, Valia JC, Barrera L, Colomina R: Intraarticular analgesia after arthroscopic knee surgery: comparison of three different regimens. Eur J Anaesthesiol 1998; 15(1): 10-5.

  9. Lyons B, Lohan D, Flynn CG, Joshi GP, O´Brien TM, McCarroll M: Intra-articular analgesia for arthroscopic meniscectomy. Br J Anaesth 1995; 75(5): 552-5.

  10. Reuben SS, Sklar J, El-Mansouri M: The preventive analgesic effect of intra-articular bupivacaine and morphine after ambulatory arthroscopic knee surgery. Anesth Analg 2001; 92(4): 923-6.

  11. Gurkan Y, Kilickan L, Buluc L, Muezzinoglu S, Toker K: Effects of diclofenac and intra-articular morphine/bupivacaine on postarthroscopic pain control. Minerva Anestesiol 1999; 65(10): 741-5.

  12. Leopold SS, Redd BB, Warme WJ, Wehrle PA, Pettis PD, Shott S: Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee. A prospective, randomized trial. JBJS Am 2003; 85-A(7): 1197-203.

  13. Adams ME, Atkinson MH, Lussier AJ, Schulz JI: The role of viscosupplementation with hylan G-F20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F20 alone, hylan G-F20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis Cartilage 1995; 3(4): 213-25.

  14. Leopold SS, Warme WJ, Pettis PD, Shott S: Increased frequency of acute local reaction to intra-articular hylan G-F20 (synvisc) in patients receiving more than one course of treatment. JBJS Am 2002; 84-A(9): 1619-23.

  15. Karlsson J, Sjögren LS, Lohmander LS: Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study. Rheumatology 2002; 41(11): 1240-8.

  16. Brandt KD, Block JA, Michalski JP: Efficacy and safety of intra-articular sodium hyaluronate in knee osteoarthritis. ORTHOVISC Study Group. Clin Orthop 2001; 38(5): 130-43.

  17. Sambrook PN, Champion GD, Browne CD: Corticosteroid injection for osteoarthritis of the knee: peripatellar compared to intra-articular route. Clin Exp Rheumatol 1989; 7(6): 609-13.

  18. Puttick MP, Wade JP, Chalmers A: Acute local reactions after intra-articular hylan for osteoarthritis of the knee. J Rheumatol 1995; 22(7): 1311-4.

  19. Forster MC, Straw R: A prospective randomized trial comparing intra-articular Hyalgan injection and arthroscopic washout for knee osteoarthritis. Knee 2003; 10(3): 291-3.

  20. Listrat V, Ayral X, Patarnello F, Bonvarlet JP, Simonnet J: Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee. Osteoarthritis Cartilage 1997; 5(3): 153-60.

  21. Smith MD, Wetherall M: A randomized placebo-controlled trial of arthroscopic lavage versus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee. Rheumatology 2003; 16(2): 220-5.

  22. Wobig M, Dickhut A, Maier R, Vetter G: Viscosupplementation with hylan G-F 20: A 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther 1998; 20: 410-23.

  23. Scale D, Wobig M, Wolpert W: Viscosupplementation of osteoarthritic knees with hylan: A treatment schedule study. Curr Ther Res 1994; 55: 220-32.

  24. Altman RD, Moskowitz R: Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: A randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998; 25: 2203-12.

  25. Carrabba MP, Paresce E, Angelini M, Re KA, Torchiana EEM, Perbellini A: The safety and efficacy of different dose schedules of hyaluronic acid in the treatment of painful osteoarthritis of the knee with joint effusion. Eur J Rheumatol Inflamm 1995; 15: 25-31.

  26. Grecomoro G, Martorana U, Di Marco C: Intra-articular treatment with sodium hyaluronate in gonarthrosis: A controlled clinical trial versus placebo. Pharmatherapeutica 1987; 5: 137-41.

  27. Huskisson EC, Donnelly S: Hyaluronic acid in the treatment of osteoarthritis of the knee. Rheumatology 1999; 38: 602-7.

  28. Dougados M, Nguyen M, Listrat V, Amor B: High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: A 1 year placebo-controlled trial. Osteoarthritis Cartilage 1993; 1: 97-103.

  29. Raman R, Dutta A, Day N, Sharma HK, Shaw CJ, Johnson GV: Efficacy of hylan G-F20 and sodium hyaluronate in the treatment of osteoarthritis of the knee. A prospective randomized clinical trial. Knee 2008; 15: 318-24.

  30. Kemper F, Gebhardt U, Meng T, Murray C: Tolerability and short-term effectiveness of hylan G-F20 in 4,253 patients with osteoarthritis of the knee in clinical practice. Curr Med Res Opin 2005; 21: 1261-9.

  31. Kahan A, Lleu PL, Salin L: Prospective randomized study comparing the medico-economic benefits of hylan G-F20 vs conventional treatment in knee osteoarthritis. Joint Bone Spine 2003; 70: 276-81.

  32. Raynauld JP, Torrance G, Band P, et al: A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F20 into the treatment paradigm for patients with knee osteoarthritis (part 1 of 2): Clinical results. Osteoarthritis Cartilage 2002; 10: 506-17.

  33. Clarke S, Lock V, Duddy J, Sharif M, Newman JH, Kirwan JR: Intra-articular hylan G-F20 (Synvisc) in the management of patellofemoral osteoarthritis of the knee (POAK). Knee 2005; 12: 57-62.

  34. Caborn D, Rush J, Lanzer W, Parenti D, Murray C: A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee. J Rheumatol 2004; 31: 333-43.

  35. Lussier A, Cividino AA, McFarlane CA, Olszynski WP, Potashner WJ, De Medicis R: Viscosupplementation with hylan for the treatment of osteoarthritis: Findings from clinical practice in Canada. J Rheumatol 1996; 23: 1579-85.

  36. Wobig M, Beks P, Dickhut A, Maier R, Vetter G: Open-label multicenter trial of the safety and efficacy of viscosupplementation with hylan G-F20 (Synvisc) in primary osteoarthritis of the knee. J Clin Rheumatol 1999; 5: S24-S31.

  37. Evanich JD, Evanich CJ, Wright MB, Rydlewicz JA: Efficacy of intraarticular hyaluronic acid injections in knee osteoarthritis. Clin Orthop Relat Res 2001; 390: 173-81.

  38. Waddell DD, Bricker D: Clinical experience with the effectiveness and tolerability of hylan G-F20 in 1047 patients with osteoarthritis of the knee. J Knee Surg 2006; 19: 19-27.

  39. Neustadt DH: Long-term efficacy and safety of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee. Clin Exp Rheumatol 2003; 21: 307-11.

  40. Kirchner M, Marshall D: A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage 2006; 14: 154-62.

  41. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G: Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2006; (2): CD005321.

  42. Wang CT, Lin J, Chang CJ, Lin YT, Hou SM: Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. J Bone Joint Surg Am 2004; 86: 538-45.

  43. Lo GH, LaValley M, McAlindon T, Felson DT: Intra-articular hyaluronic acid in treatment of knee osteoarthritis. A metaanalysis. JAMA 2004; 290: 3115-21.




2020     |     www.medigraphic.com