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2010, Número 4

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Neumol Cir Torax 2010; 69 (4)


Anhidrasa carbónica, nuevas perspectivas

Espinosa ML, Sierra VMP

Idioma: Español
Referencias bibliográficas: 82
Paginas: 200-209
Archivo PDF: 264.48 Kb.


RESUMEN

La anhidrasa carbónica es una metaloenzima zinc dependiente, juega un papel importante en la catálisis reversible de la hidratación del CO2 para formar HCO3- y H+. De las cinco familias descritas, la AC-α se encuentra en los seres humanos, ésta se divide en cuatro subgrupos y catorce isoformas. Su amplia distribución celular, le confiere una versátil funcionalidad. Los estudios reportados recientemente nos llevan a cuestionarnos acerca del papel que esta enzima juega en la génesis, el control y progreso de las enfermedades pulmonares, como asma, EPOC e inclusive la aterosclerosis y cáncer.


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