L¨®pez MA , Ramos LA

Idioma: Español
Referencias bibliográficas: 32
Paginas: 38-44
Archivo PDF: 656.73 Kb.

RESUMEN

Los miembros de la superfamilia del factor de crecimiento transformante-beta (TGF-¦Â) son factores de crecimiento que son secretados y poseen varias funciones importantes en laproliferaci¨®n, diferenciaci¨®n y adhesi¨®n celular. La familia del TGF-¦Â est¨¢ dividida en tres grupos principales: los TGF-¦Âs, las activinas y las prote¨ªnas morfogen¨¦ticas del hueso (BMP¡¯s). Enlos mam¨ªferos existen tres isoformas de TGF-¦Â, los TGF-¦Â 1, 2 y 3. La isoforma TGF-¦Â se encuentra de forma predominante en la mayor¨ªa de los tejidos, y es producida por varios tipos celulares del linaje de los leucocitos, en donde se incluyen linfocitos, macr¨®fagos, c¨¦lulas dendr¨ªticas y plaquetas, y su expresi¨®n act¨²a tanto en una forma aut¨®crina como paracrina para controlar los procesos mencionados anteriormente. Sin embargo, actualmente la activaci¨®n del TGF-¦Â latente (inactivo); en consecuencia, unaproducci¨®n elevada de esta citosina ha sido ligada a defectos inmunes asociados con enfermedades y des¨®rdenes autoinmunes, susceptibilidad a infecciones oportunistas y a complicaciones fibr¨®ticas asociadas a condiciones inflamatorias cr¨®nicas. En este trabajo, el objetivo fue el de realizar una revisi¨®n de las propiedades inmunorregulatorias del TGF-¦Â en el contexto de las infecciones parasitarias.

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