Baptista-González HA, Rosenfeld-Mann F, Trueba-Gómez R, Enríquez-Pérez MM, Vidal-González VM

Idioma: Español
Referencias bibliográficas: 29
Paginas: 167-174
Archivo PDF: 299.18 Kb.

RESUMEN

Objetivo: Describir la asociación en la frecuencia, especificidad y concentración de los anticuerpos anticardiolipina (ACA) y antinucleares (ANA) en distintos grupos de mujeres en edad reproductiva. Material y métodos: Mediante un estudio con diseño transversal, se evaluaron a mujeres no embarazadas (grupo 1), gestantes con bajo riesgo perinatal (grupo 2) y pacientes con pérdida gestacional recurrente (grupo 3). Resultados: Se incluyeron 567 mujeres, con 236, 175 y 156 casos por cada grupo. La prevalencia de los ACA fue de 2.5, 0.6 y 25.6% para cada grupo, con mayor asociación en las pacientes del grupo 3 vs grupo 1 y grupo 2 (OR 13.2, IC 95% 5.45-32.0 y OR 60.0, IC 95% 8.13-442.0). La frecuencia de los ANA fue de 18.6, 10.36 y 34.6%, con diferencias entre el grupo 3 vs grupo 1 (OR 2.3, IC 95% 1.4-2.3) y grupo 2 (OR 4.6, IC 95% 2.5-8.3). Las mujeres con ACA IgG, tuvieron mayor probabilidad de tener ANA positivo (OR 14.3, IC 95% 6.1-33.0) y anti-ssDNA (OR 17.4, IC 95% 7.8-38.8). Las gestantes no mostraron mayor prevalencia de autoanticuerpos. Conclusiones: La frecuencia de ACA y ANA resultó mayor en mujeres con pérdida gestacional recurrente. Los casos reactivos de ANA lo fueron a bajas concentraciones y forman parte del repertorio de autoanticuerpos naturales.

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