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2010, Número 3

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Gac Med Mex 2010; 146 (3)


El origen de la variabilidad genética de los virus de la influenza

Salazar MI, López-Ortega O, León-Ávila G, Ramírez-Gónzalezc JE, Castro-Mussot ME

Idioma: Español
Referencias bibliográficas: 66
Paginas: 199-206
Archivo PDF: 135.86 Kb.


RESUMEN

Para comprender la gran variabilidad de los virus de la influenza es necesario entender no solo su configuración genética, sino las consecuencias a la que ésta conlleva en términos de la variación que provoca en las proteínas que participan en su replicación y las que constituyen la superficie de la partícula viral. El origen de los grandes cambios en estos virus se debe, en primer lugar, a su genoma segmentado que puede sufrir reasociaciones y, en segundo, a la tasa de error de la polimerasa, responsable de copiar los genes contenidos en estos segmentos. Estos dos mecanismos combinados confieren la plasticidad genética que origina con cierta frecuencia la emergencia de nuevos virus de la influenza en la naturaleza.


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